The Influence of Fat Suppression Technique on Diffusion-weighted (DW) MRI in Lung Cancer
Journal Title: JOURNAL OF ADVANCES IN PHYSICS - Year 2017, Vol 13, Issue 10
Abstract
Purpose: To qualitatively and quantitatively investigate the effect of common vendor-related sequence variations in fat suppression techniques on the diagnostic performance of free-breathing DW protocols for lung imaging.Methods: 8 patients with malignant lung lesions were scanned in free breathing using two diffusion-weighted (DW) protocols with different fat suppression techniques: DWA used short-tau inversion recovery (STIR), and DWB used Spectral Adiabatic Inversion Recovery (SPAIR). Both techniques were obtained at two time points, between 1 hour and 1 week apart. Image quality was assessed using a 5-point scoring system. The number of lesions visible within lung, mediastinum and at thoracic inlet on the DW (b=800 s/mm2) images was compared. Signal-to-noise ratios (SNR) were calculated for lesions and para-spinal muscle. Repeatability of ADC values of the lesions was estimated for both protocols together and separately.Results: There was a signal void at the thoracic inlet in all patients with DWB but not with DWA. DWA images were rated significantly better than DWB images overall quality domains. (Cohens κ = 1). Although 8 more upper mediastinal/thoracic inlet lymph nodes were detected with DWA than DWB, this did not reach statistical significance (p = 0.23). Tumour ADC values were not significantly different between protocols (p=0.93), their ADC reproducibility was satisfactory (CoV=7.7%) and repeatability of each protocol separately was comparable (CoVDWA=3.7% (95% CI 2.5 7.1%) and CoVDWB=4.6% (95% CI 3.18.8%)).Conclusion: In a free-breathing DW-MRI protocol for lung, STIR fat suppression produced images of better diagnostic quality than SPAIR, while maintaining comparable SNR and providing repeatable quantitative ADC acceptable for use in a multicentre trial setting.
Authors and Affiliations
Alexander Weller, MV Papoutsaki, M Orton, D Ap Dafydd, C Kelly Moreland, Mary O’Brien, V Morgan, D Collins, NM DeSouza
Keywords
Related Articles
- EP ID EP653438
- DOI 10.24297/jap.v13i10.6113
- Views 83
- Downloads 0
ELECTROMAGNETIC ELECTRON-CYCLOTRON WAVES WITH AC FIELD IN THE MAGNETOSPHERE
In this paper the effect of externally injected beam of cold electrons on electromagnetic electron-cyclotron (EMEC) waves in the magnetosphere has been discussed. The investigation is conducted using the methodology of c...
Magnetic and dielectric properties of BiFeO3 nanoparticles
Single crystalline nano-sized multiferroic BiFeO3 (BFO) powders were synthesized through simple chemical co-precipitation method using polyethylene glycol (PEG) as capping agent. We obtained pure phase BiFeO3 powder by c...
By A Law of Motion into The Cause of Gravity
This is an essay written by me when I was yet in my younger years, since then I have simplified the same in several other papers. It intrigues me in my old age now to behold my state of mind in those days long ago. This...
Considering skin physiology in capacitive-coupled hyperthermia
Dominant technical solution for oncological hyperthermia devices is capacitive-coupling. However, it has the challenge of overheating the surface of adipose layers and burning cutaneous structures. The main technical sol...
Studies on Raman Spectra of Cu2+ Ion Doped B2O3-K2O-ZnO-BaO Glasses
Glasses with compositions 59B2O3-10K2O-(30-x)ZnO-xBaO-1CuO were prepared using melt quenching technique. The effect of BaO content in present glass system doped with copper ion in place of ZnO has been studied with respe...