The influence of metabolites from wild type and mutant strains of Schizophyllum commune on Escherichia coli induced changes in Albino rats
Journal Title: Scholars Academic Journal of Biosciences - Year 2013, Vol 1, Issue 4
Abstract
The increasing emergence of several multi-resistant pathogenic microorganisms to synthetic drugs has drawn much attention of researchers to finding new, attractive and natural products such as mushroom species as neutraceuticals because they contain a tremendous variety of secondary metabolites. Hence this work is reported on the influence of metabolites fromSchizophyllum commune wild type and mutants on Escherichia coli induced histopathological changes in Albino rats. S. commune mutant strains were generated by exposing the wild type fungus to ultraviolet rays at various time intervals of 30minutes, 60minutes and 90minutes coded as SCM1, SCM2 and SCM3 respectively. Metabolites from submerged fermentation of the S.commune strains were tested on Albino rats administered with pathogenic E.coli. Histopathological studies carried out on the testes, kidney and liver of the rats showed that SCM2 metabolite performed best in combating the virulence effects of pathogenic E.coli in the testes, kidney and liver tissues of the albino rats as compared to performance of SCM3, SCM1 and SCW respectively, hence SCM2 is recommended for use instead of the wild type in drug production. Keywords: Metabolites, Schizophyllum commune, Albino rats, Submerged fermentation.
Authors and Affiliations
Aina . , Alatise . , Akeredolu . , A. A. , Oloke . , J. K. , F. A, Omomowo . , D. A. , I. O.
Asherson’s syndrome: A Case Report
Catastrophic APS (CAPS) is the most severe form of Antiphospholipid antibody syndrome with multiple organ involvement which occurs over a short period of time, usually associated with microthrombosis. We report a case of...
The Electrical Bidomain Model: A Review
Abstract: Bidomain model is a mathematical representation of the anisotropic electrical properties of cardiac tissue. It is used to simulate cardiac electrical tissue computationally and to study the stimulation of cardi...
Occurrence of Escherichia coli on the Water Resources at Barangays Linao East and Linao West, Tuguegarao City
Abstract: This study was conducted to evaluate the bacterial load of water from the pump well used by the residents of Linao East and West in Tuguegarao City for the reason that the Barangay is located in a low lying are...
Improved RNA Extraction Technique for Tropical Plants
Abstract: The study was aimed to compare the relative yield, purity and integrity of RNA extracted from leaf tissues of different plants using the modified CTAB method developed by Chang et al. 1993. Extraction of RNA is...
Low Dose 5-Azacytidine Treatment Induce in KYSE450 Esophageal Carcinoma Cell Line
The objective is to discuss the treatment effects of low doses of 5 – Azacytidine to KYSE450 esophageal cancer cell line. The cells of KYSE450 esophageal cancer cell line were used different drug concentrations of 5-Aza...