THE INFLUENCE OF SUCROSE ESTER SURFACTANTS AND DIFFERENT STORAGE CONDITIONS ON THE PREPARATION OF A NOVEL SWIETENIA MACROPHYLLA OIL NANO-EMULSION
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6
Abstract
Nano-emulsions are emulsions with uniform and extremely small droplet sizes, typically in the range of 20–200 nm. Nano-emulsion concept has attracted considerable attention in recent years for its application in personal care and cosmetic products also due to their ability to improve the penetration and permeation of active ingredients through the skin. A composition of sucrose ester as surfactant, glycerol and Swietenia macrophylla oil were used to produce nano-emulsion by simple mixing and applying heat to dissolve the sucrose ester in the glycerol then adding the oil to the mixture. Three different types of sucrose ester (laureate, oleate and palmitate) were used to investigate their influence on the production of nano-size emulsion. Sucrose laureate produced nano-emulsion with good droplet size, polydispersity index and negative zeta potential compared to oleate and palmitate. The oil droplet size produced using sucrose laureate was below 200 nm with polydispersity index 0.2 and negative zeta potential lower than -40 mV. Stability study was conducted for the nano-emulsion at different temperatures (4 °C, 25 °C and 40 °C) for six months. Nano-emulsion formulation was very stable at 4 °C compared to 25 °C and 40 °C while at 25 °C showed moderate stability but it was unstable at 40 °C. The nano-emulsion containing the novel Swietenia macrophylla oil was successfully prepared using sucrose laureate and the ideal storage condition for nano-emulsion was 4 °C.
Authors and Affiliations
Mustafa Eid Ahmad , Saringat Baie , Osama Arafat
Keywords
Related Articles
- EP ID EP103460
- DOI -
- Views 80
- Downloads 0
FORMULATION AND EVALUATION OF ACECLOFENAC FAST DISSOLVING TABLETS
The purpose of this study was to develop fast dissolving tablets of Aceclofenac using different concentration superdisintigrents.Fast dissolving tablets of Aceclofenac were prepared by wet granulation technique using s...
ANTIMICROBIAL ACTIVITY OF THE FRUIT-SEEDS MADHUCA LONGIFOLIA (KOENIG)
The investigation was carried out to study the antibacterial activity of the Madhuca longifolia(Koenig) in gram positive and gram negative organism.. Antimicrobial activity of the acetone and aqueous extracts of M.longif...
INDUSTRIAL PROCESS VALIDATION OF SOLID ORAL DASAGE FORM: A REVIEW
Validation is the important step in gaining and maintaining the quality of the final product. Validation of the individual steps of the processes is called the process validation. Different dosage forms have different va...
A TEN YEAR STUDY OF THE MANAGEMENT OF HAEMORRHOIDS AT A SECONDARY NURSING HOME IN SOUTH WEST NIGERIA
This retrospective study evaluated the different treatment options used in the management of haemorrhoids in a state government owned secondary hospital, Jericho Nursing Home, Ibadan, Nigeria. The study was conducted for...
DRY GRANULATION TECHNIQUE FOR CONVERTING TRIPHALA CHURNA AS GRANULES, TABLETS AND ORGANOLEPTIC EVALUATION
The objective of this research work was the conversion of Triphala churna into stable, palatable and patient acceptable granules to swallow conveniently by dry granulation methods, using suitable binding agents. The chur...