The influence of the eutectic mixtures: salicylic acid – menthol and benzocaine – menthol on physical properties of the creams with fluconazole
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 4
Abstract
Fluconazole is used in treatment of the surface mycoses of the skin. Menthol, salicylic acid and benzocaine are the components of many preparations for topical use. When mixed they form the eutectic mixtures. The purpose of our research was to prepare the antifungal creams with fluconazole containing eutectic mixture: menthol-salicylic acid or menthol-benzocaine and to compare and estimate the influence of these mixtures on physical properties of these preparations. At the beginning, the creams were subjected to physical tests such as spreadability, slip and tenacity. Further, the rheological properties were evaluated. The fluconazole creams with eutectic mixtures had better physical properties. The rheological studies, based on Ostwald de Waele model, showed the pseudoplastic character of flowing at 32ºC and the correlation between the rheological parameters and the composition of the creams. Moreover, all the preparations had thixotropic properties.
Authors and Affiliations
Maria Zuń, Katarzyna Wojciechowska, Dorota Dwornicka, Ewa Poleszak
Keywords
Related Articles
- EP ID EP158068
- DOI -
- Views 104
- Downloads 0
Influence of N-(p-acetylphenyl)-p-isopropoxyphenylsuccinimide on the protective action of classical antiepileptic drugs against maximal electroshock-induced seizures in mice
The aim of this study was to determine the effects of N-(p-acetylphenyl)-p-isopropoxyphenylsuccinimide (APIPPS) on the protective action of four classical antiepileptic drugs (AEDs: carbamazepine [CBZ], phenobarbital [PB...
Assessment of using additional means of oral hygiene on the state of the hard tissue of teeth in 12-13 year old children living in the Lublin province
The impact of additional means of oral hygiene (rinses, dental floss, dental irrigators, toothpicks) on the state of the hard tissue of teeth was assessed in 12-13 year old children living in the Lublin province. In...
The influence of the viscosity of the ointment vehicles magisterial topical preparations, on the speed transfer of biologically active substances
The aim of this study was to analyze the morphological parameters (viscosity, viscous elasticity and the rate of volatile component loss) of salicylic and boric acid-containing magisterial formulae (ointments). Moreover,...
The influence of selected variables on the values of systolic pressure in patients with hypertension
Hypertension is a disease of the first world and results to a great extent from leading an improper lifestyle. Some important risk factors include being overweight or obese, indulging in little physical activity, smokin...
A review of TTS – development, types and preparations
Transdermal Therapeutic Systems (TTS) are elastic multi-layer patches applied to the skin in order to deliver active substances into the bloodstream. One advantage of a transdermal drug delivery route over other types of...