The Influence of Tranexamic Acid on Platelet Function in Patients Undergoing Open Heart Surgery Using Cardiopulmonary Bypass (CPB)
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 4
Abstract
Introduction: Platelet dysfunction is consideredto be a major cause of bleeding after cardiac surgery following tranexamic Cardiopulmonary Bypass (CPB), resulting in an increased need for transfusions. Lysine analogues such as acid, inhibit fibrinolysis by attachment to the lysine binding sites on plasminogen and plasmin and prevent fibrinolysis by blocking engagement of these fibrinolytic proteins with fibrinogen and fibrin. Aim: In this study, we sought to determine whether Regimen 1 (continuous infusion of tranexamic acid) preserves platelet function when compared to Regimen2 (bolus dose of tranexamic acid). Material and Methods: Regimen1 Tranexamic acid 10mg/kg IV after induction before skin incision followed by 1mg/kg/hr infusion. Regimen2 Tranexamic acid 10mg/kg IV after induction before skin incision followed by 5mg/kg bolus in pump prime and 5mg/kg IV after protamine administration. Results: There was no statistically significant difference between the two groups or within the same group at different time periods with regard to platelet aggregation. Conclusion: Either continuous or intermittent methods of tranexamic acid in patients undergoing open heart surgery may be used for pharmacological prophylaxis for bleeding.
Authors and Affiliations
Geeta Kanithi
Keywords
Related Articles
- EP ID EP472303
- DOI 10.21088/ijaa.2349.8471.4417.15
- Views 87
- Downloads 0
Randomised Clinical Trial on Effect of Adding Magnesium Sulphate with 0.75% Ropivacaine and Dexmedetomidine with 0.75% Ropivacaine in Patients Undergoing Elective Laparotomy in a tertiary care hospital
Background: Laparotomies requires a good amount of pain relief postoperatively to avoid delay in recovery and reduce the duration of stay in the hospital. Among multiple modalities of pain relief postoperative wound infi...
Comparative Clinical Evaluation Between Intrathecal Bupivacaine (0.5%) Heavy, Bupivacaine with Nalbuphine and Bupivacaine with Butorphanol for Infra Umblical Surgeries
Introduction: Spinal anaesthesia is a very popular and common regional anaesthesia technique for infra umbilical surgeries. However the short duration of action of local anaesthetic drugs used for spinal anesthesia resul...
Comparison of I-GelTM and LMA ProSealTM as Airway Device for Laparoscopic Hernioplasty
Background and Aims: Supraglottic device can provide adequate ventilation for laparoscopic surgeries. This study was aimed to compare Proseal Laryngeal Mask Airway and IGel as airway device in laparoscopic hernioplasty....
Comparison of Dexmedetomidine and Propofol on Haemodynamics, Ionic Balance and Postop Sedation in Brachial Plexus Repair Surgery: An Entropy Guided Prospective Trial
Context: Propofol is the commonly used intravenous drug to maintain adequate depth of anaesthesia in brachial plexus repair surgery under general anaesthesia without muscle relaxant. It has rapid onset of action, a...
Four Segments Versus two Segments Paravertebral Block for Inguinal Hernia Repair
Background: Paravertebral block (PVB) has been successfully used to provide good analgesia with fewer side effects in inguinal herniorrhaphy. So, the present study was conducted to compare the characteristics of two segm...