The Influence of Vancomycin and Linezolid on the Phagocytic Activity of Blood Neutrophils in vitro Experiments in Preterm Newborns with “Ventilator-Associated” Pneumonia
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2017, Vol 7, Issue 9
Abstract
The article is devoted to the study of the influence of vancomycin and linezolid antibiotics on the phagocytic activity of blood neutrophils in vitro studies among 15 premature newborns with ventilator-associated pneumonia. The stimulating effect of linezolid in 12 infants on neutrophil phagocytosis was established with an increase of phagocytic number, index of phagocytosis and completion index of phagocytosis by 40% or more of the initial values. Vancomycin inhibited phagocytosis of neutrophils in 1 or 2 indicators by 32% or more in six infants. The phagocytic activity of neutrophils in these infants was normalized in the recovery period. Therefore, the majority of newborns with ventilator-associated pneumonia, linezolid and vancomycin was not affected negatively on the phagocytic activity of blood neutrophils.
Authors and Affiliations
Maria Vasilievna Kushnareva, Alexandr Yuryevich Gerasimov, Elena Solomonovna Keshishyan, Alexey Vladimirovich Semenov
Keywords
Related Articles
- EP ID EP312969
- DOI -
- Views 60
- Downloads 0
Symptoms and Management of Glue Ear in School Going Children: A Prospective Study
Aims To document clinical profile (presenting manifestation, hearing assessment) of persistent otitis media with effusion (OME) with hearing impairment in children. To compare the improvement in hearing after non-surgica...
Novel Vesicular Carrier for Enhanced Transdermal Delivery of Tramadol Hydrochloride Transfersomal Gel
The main aim of current probe is to formulate and evaluate transfersomal gel for effective transdermal delivery of Tramadol Hcl. It was investigated by encapsulating the drug in various formulations which composed of var...
Optimum Initiating Pressure of Nasal CPAP in Newborns with Moderate Respiratory Distress: A Randomised Controlled Trial
Objective To decide the optimum initiating pressure of nasal CPAP in newborns with respiratory distress. Methods The study was done in neonatal intensive care unit (NICU) between November 2009 and November 2011 as a pros...
Review on Pressure Sores
Pressure sore is a localised injury to the skin and underlying tissue caused due to unrelieved pressure on pressure points or bony prominences. The predisposing factors causing pressure ulcers are both intrinsic and extr...
Effects of Chicken Extract on the Serotonergic System of Mice Loaded with Restraint Stress
Chicken extract (CE), which is composed of water-soluble substances extracted from chicken by double boiling, could enhance mental efficiency and are helpful to the recovery from postpartum sickness and mental fatigue. B...