The Influence of Vancomycin and Linezolid on the Phagocytic Activity of Blood Neutrophils in vitro Experiments in Preterm Newborns with “Ventilator-Associated” Pneumonia
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2017, Vol 7, Issue 9
Abstract
The article is devoted to the study of the influence of vancomycin and linezolid antibiotics on the phagocytic activity of blood neutrophils in vitro studies among 15 premature newborns with ventilator-associated pneumonia. The stimulating effect of linezolid in 12 infants on neutrophil phagocytosis was established with an increase of phagocytic number, index of phagocytosis and completion index of phagocytosis by 40% or more of the initial values. Vancomycin inhibited phagocytosis of neutrophils in 1 or 2 indicators by 32% or more in six infants. The phagocytic activity of neutrophils in these infants was normalized in the recovery period. Therefore, the majority of newborns with ventilator-associated pneumonia, linezolid and vancomycin was not affected negatively on the phagocytic activity of blood neutrophils.
Authors and Affiliations
Maria Vasilievna Kushnareva, Alexandr Yuryevich Gerasimov, Elena Solomonovna Keshishyan, Alexey Vladimirovich Semenov
Keywords
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