The Inhibitory Activity on the Rate of Prostaglandin Production by Zingiber officinale var. Rubrum
Journal Title: Pharmacology and Clinical Pharmacy Research - Year 2016, Vol 1, Issue 1
Abstract
Red ginger (Zingiber officinale var. Rubrum) is widely used by Indonesian as a traditional medicine to treat inflammation. The aim of this research was to provide information regarding the inhibitory activity of red ginger rhizome infusion on the rate of prostaglandin production. The red ginger rhizome used in this research was collected from Manoko plantation, Lembang. This research was conducted by Colorimetric COX Inhibitor Screening Assay method using TMPD (N,N,N’,N’-tetramethyl-p-phenylendiamine) as reagent. Phytochemical screening showed that flavonoid, quinone, and monoterpenoid/sesquiterpenoid were detected in both dried herbs and water extract. Three spots were detected on thin-layer chromatography system with a mobile phase of chloroform:methanol (5:5). The rate of prostaglandin formations either by red ginger rhizome infusion or acetylsalicylic acid on COX-1 is slower (at 25th minutes) rather than COX-2 (5th minutes). The strength of cyclooxygenase by red ginger rhizome infusion is weaker than acetosal.
Authors and Affiliations
Fauzan Fikri, Nyi M. Saptarini, Jutti Levita
Keywords
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