The inhibitory effects of Yigan Jiangzhi formula on hepatic metastasis of colorectal cancer
Journal Title: TMR Integrative Medicine - Year 2020, Vol 4, Issue 9
Abstract
Background: To observe the inhibitory effects of Yigan Jiangzhi formula (liver-supplementing lipid-lowering formula, YGJZF) on hepatic metastasis of colorectal cancer. Methods: The hepatic metastasis BALB-c mice model of colorectal cancer was established by injecting HCT-116 cell suspension following splenectomy. Next, we randomly divided BALB-c mice into 5 groups, which were blank group, model group (tumor only), traditional Chinese medicine group (YGJZF), western medicine group (capecitabine), combined group (YGJZF and capecitabine), respectively. After 14 days treatment, the effects of different treatments were evaluated the serological indicators were evaluated, including the levels of alanine transaminase, aspartate transaminase, triglyceride, total cholesterol and vascular endothelial growth factor (VEGF) by ELISA. Results: Except the blank group, the other groups showed diffuse hepatic metastasis. Compared with the model group, the total number and weight of the metastatic tumors as well as serological indicators in medicine-given groups were sharply reduced (P < 0.05 for all) the combined group had better effects. The serum levels of these indicators showed no statistical difference among each medicine-given group (P > 0.05), but the combined group has a remarkable decrease of all the indicators than in western medicine group. Conclusion: YGJZF not only can inhibit the hepatic metastasis of colorectal cancer in BALB-c mice, but also affect the levels of hepatic enzymes and lipids. Meanwhile, it can reduce the expression of VEGF. All these results indicate that YGJZF, which lowers down lipids and protects hepatic functions, has the potential to block VEGF pathway, contributing to the inhibition of hepatic metastasis.
Authors and Affiliations
Yuan-hong Zhao, Qian-qian Niu, Quan-zheng Li, Ji-hong Yin, Yu Lu, Zheng Li
Keywords
Related Articles
- EP ID EP682808
- DOI 10.12032/TMRIM202004009
- Views 302
- Downloads 0
The effects of inhaled aromatherapy on complications of hemodialysis patients: a systematic review
Objective: To evaluate the effect of inhaled aromatherapy on complications in patients undergoing hemodialysis. Methods: We search the PubMed, Web of Science, Cochrane Library, Embase and China Biomedical Literature Data...
Participating in health care for total hip replacement patients: an integrative review
In recent years, with the continuous improvement of people's health requirements, the awareness of participating in disease diagnosis and treatment has also been constantly enhanced. Patient’s participation has become a...
A network pharmacology approach to explore the mechanism of Kangguan decoction in the treatment of coronavirus disease 2019 with preliminary verification
Objective: To explore the mechanism of Kangguan decoction in the treatment of coronavirus disease 2019 (COVID-19) and then perform preliminary verification. Methods: The effective compounds and target genes of Kangguan d...
Home versus centre-based Pulmonary rehabilitation for patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
Background: To evaluate the effects of home versus centre-based pulmonary rehabilitation on exercise capacity, quality of life, and dyspnoea scores in patients with chronic obstructive pulmonary disease by meta-analysis....
Analysis of the relationship between liver-qi stagnation and premature ovarian failure based on exosomes
The incidence of premature ovarian failure, which is related to women’s excessive pressure and mental tension, has increased in recent years. Premature ovarian failure has become one of the diseases that seriously distur...