The inSIGHT study: costs and effects of routine hysteroscopy prior to a first IVF treatment cycle. A randomised controlled trial
Journal Title: BMC Women's Health - Year 2012, Vol 12, Issue
Abstract
In in vitro fertilization (IVF) and intracytoplasmatic sperm injection (ICSI) treatment a large drop is present between embryo transfer and occurrence of pregnancy. The implantation rate per embryo transferred is only 30%. Studies have shown that minor intrauterine abnormalities can be found in 11–45% of infertile women with a normal transvaginal sonography or hysterosalpingography. Two randomised controlled trials have indicated that detection and treatment of these abnormalities by office hysteroscopy after two failed IVF cycles leads to a 9–13% increase in pregnancy rate. Therefore, screening of all infertile women for intracavitary pathology prior to the start of IVF/ICSI is increasingly advocated. In absence of a scientific basis for such a policy, this study will assess the effects and costs of screening for and treatment of unsuspected intrauterine abnormalities by routine office hysteroscopy, with or without saline infusion sonography (SIS), prior to a first IVF/ICSI cycle.
Authors and Affiliations
Janine G Smit, Jenneke C Kasius, Marinus JC Eijkemans, Carolien AM Koks, Ron Van Golde, Jurjen GE Oosterhuis, Annemiek W Nap, Gabrielle J Scheffer, Petra AP Manger, Annemiek Hoek, Mesrure Kaplan, Dick BC Schoot, Arne M van Heusden, Walter KH Kuchenbecker, Denise AM Perquin, Kathrin Fleischer, Eugenie M Kaaijk, Alexander Sluijmer, Jaap Friederich, Joop SE Laven, Marcel van Hooff, Leonie A Louwe, Janet Kwee, Jantien J Boomgaard, Corry H de Koning, Ineke CAH Janssen, Femke Mol, Ben WJ Mol, Helen L Torrance, Frank JM Broekmans
Keywords
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- EP ID EP679505
- DOI 10.1186/1472-6874-12-22
- Views 25
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