THE INTERACTION OF DPPHRADICAL WITH CIS-TETRACHLORODI-µ-CARBOXYLATES OF DIRHENIUM(III)
Journal Title: Вісник Одеського національного університету. Хімія - Year 2016, Vol 21, Issue 3
Abstract
The antiradical activity of cis-tetraсhlorodi-μ-carboxylate of dirhenium(III) with 2,2-diphenyl-1-picrylhydrazyl (DPPH) was studied by electron absorption spectroscopy.It is known that in the visible region of the spectrum DPPH contains the characteristic absorption maximum at 540 nm (in 1,2-dichloroethane), the antiradical activity of the investigated substances is determined by the change in the intensity of this band. 1,2-dichloroethane and methanol was used as solvent for the reaction with DPPH, which allows to establish depen-dence of the reaction rate on the nature of the solvent.As a result of the interaction of the characteristic intensity gradually decreases (for DPPH) absorption maximum at 540 nm and a specific purple color of the solution disappears. Such changes in the spectrum indicates a transition DPPH to non-radical form. Thus, it is shown that the investigated substances exhibit antiradical properties. The dependence of this interac-tion from the nature of the equatorial ligands and solvent were shown. Using the complex compounds of rhenium(III) with the equatorial ligands – ferulic and in-dole-3-acetic acids which contain multiple bonds, leads to an increase rate of reaction with free radicals of 3-4 times in 1,2-dichloroethane at 40-80 times in methanol in comparison with analogous alkyl derivatives.At the same time increasing the length and branching of alkyl groups leads to a slowdown in the antiradical activity. In addition, the acceleration of the reaction with the radical also oc-curs by increasing of electron donation and solvating properties of the solvent. So for complex compounds of rhenium(III) with ferulic acid in methanol reaction is about 30 times faster than in 1,2-dichloroethane. On the example of interaction of cis-tetraсhlorodi-μ-carboxylate of dirhenium(III) with a model DPPH radical, it was shown that complex compounds of rhenium with the quadruple metal-metal bond can be used as drugs with antiradical activity, reducing the intensity of free radical oxidation in various diseases in living organisms.
Authors and Affiliations
S. Y. Treyak, A. A. Golichenko, A. V. Shtemenko
Keywords
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- EP ID EP337155
- DOI 10.18524/2304-0947.2016.3(59).79588
- Views 79
- Downloads 0
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