Τhe interwoven intracellular signalling pathway of insulin<br /> and its role in the polycystic ovary syndrome <br />
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2002, Vol 19, Issue 1
Abstract
The mode of action of hormones and the intracellular signalling pathways comprise a continuous object of research, especially in the case of insulin, a hormone with a variety of systematic actions. Studies suggest that the elucidation of the tyrosine phosphorylation cascades was insufficient to explain the diversity of insulin effects and point to the implication of additional signalling mechanisms. There is a body of evidence involving the interaction of the insulin receptor, either directly or indirectly, with G-proteins and inositol phosphoglycans (IPGs). In this review the role of these two major secondary messengers in insulin signalling is analyzed and a novel insulin signalling pathway using tyrosine kinase, inositol phosphoglycan and G-proteins is presented with particular therapeutic reference to the treatment of the polycystic ovary syndrome (PCOS).
Authors and Affiliations
E. DIAMANTI-KANDARAKIS, G. ANTONOGEORGOS
Keywords
Related Articles
- EP ID EP139212
- DOI -
- Views 72
- Downloads 0
The role of management in evidence-based practice implementation and healthcare qu
A number of factors have been documented that affect the implementation of evidence-based practice (EBP) in health care, among which leadership and management have a crucial role. Frequently, the managers and the leaders...
Anabolic steroids: A review of the literature
Anabolic steroids are synthetic derivatives of testosterone. The use of anabolic steroids has spread considerably over recent decades, attracting the attention not only of professional athletes but also of the wider popu...
Θεραπευτικές στρατηγικές στην οξεία μυελογενή λευχαιμία νέων ενηλίκων
Η θεραπεία της οξείας μυελογενούς λευχαιμίας (ΟΜΛ) περιλαμβάνει αρχικά την αγωγή με κυτταροτοξικά χημειοθεραπευτικά, με στόχο την εκρίζωση των κακοήθων κυττάρων και την αποκατάσταση φυσιολογικής αιμοποίησης από τα υπολει...
Normative values for physical fitness of Greek boys and girls aged 6–18 years
OBJECTIVE To establish updated normative values of physical fitness in Greek children aged 6 to 18 years for the following measures: 20 m shuttle run, standing long jump, sit-and-reach, 10×5 m shuttle run and sit-ups, an...
Retrotracheal diving goiter
No abstract available