The investigation of herbal medicine Holelesan® in patients with functional pathology of biliary system and intestine
Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 1
Abstract
Objective — to investigate efficacy of the herbal drug Holelesan® in the treatment of patients with functional diseases of the biliary tract (FDBT) in combination with irritable bowel syndrome with constipation (IBS-C). Materials and methods. The examinations involved 60 patients with IBS-C in combination with FDBT (gallbladder dysfunction) aged 18 to 65 years (mean age 39.2 ± 3.1 years). Among them, there were 41 women (68.3 %) and 19 men (31.7 %). The diagnosis of IBS-C and FDBT was established on the basis of the Rome IV diagnostic criteria. Patients were allocated into two groups, 30 patients in each: subjects of the first group received Holelesan® (Arterium production) 2 capsules 3 times a day 30 minutes before meals, patients in the second group took artichoke preparation in a dose of 400 mg 3 times a day. The duration of treatment was 20 days. A number of investigations and assessments were performed at the baseline and on the 21st day of treatment: the frequency of bowel movements, the nature of the stool according to the Bristol scale (BS), the severity of abdominal pain on a visual analogue scale (VAS), the contractility of the gall bladder was determined sonographically during the food load test. The syndrome of intestinal bacterial overgrowth (SIBO) was assessed with lactulose H2-respiratory test. Results. After 3 weeks of treatment, patients in the first group demonstrated an improvement in their condition, manifested in a decrease in the intensity of pain by 51 %, up to 3.5 ± 0.8 cm on VAS (p = 0.01), absence of pain was reported by 23.3 % of patients. The frequency of defecation doubled to 2.4 ± 0.6 times/week (p = 0.08), and the shape of the stool in BS reached 3.3 ± 0.6 (p = 0.045). The stool of 3 — 4 type was defined in 56.7 % of patients. Moreover, an improvement in the contractile gallbladder function was established, while the gallbladder ejection fraction reached 45.3 ± 6.1 % (p = 0.05), and biliary sludge was significantly reduced and was observed in 23.3 %, which was initially present in 40 % of patients. The SIBO rate decreased almost twice after the treatment (in 43.3 % of patients in this group p > 0.05). The improvement was also registered in patients of the second group. The VAS pain intensity decreased by one third and amounted to 4.6 ± 0.8 cm (p = 0.06) (absence of pain was reported by 10 % of patients). The frequency of bowel movements in this group increased by 50 % and amounted 2.1 ± 0.4 times/week, (p = 0.17), the shape of the stool in BS corresponded to 2.2 ± 0.5 (p = 0.37), normal stool was noted by the end of the study in 26.7 % of patients. The gallbladder ejection fraction in patients of this group was 43.8 ± 6.0 % (p = 0.047). After treatment, the SIBO was defined in 63.3 % of patients (p > 0.05). Conclusions. The natural herbal multicomponent medication Holelesan® has a significant cholekinetic, laxative and prebiotic effects and can be recommended for the treatment of the functional pathology of the biliary tract and irritable bowel syndrome with constipation.
Authors and Affiliations
A. E. Dorofeyev, M. M. Rudenko
Keywords
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- EP ID EP508312
- DOI 10.30978/MG-2019-1-53
- Views 99
- Downloads 0
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