The long QT syndrome
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2007, Vol 24, Issue 6
Abstract
The long QT syndrome is characterized by prolongation of the QT interval. Congenital syndromes related to QT prolongation and syncope or even sudden death were described many years ago. More recently six genetic loci for these congenital forms have been identified. Mutations in these genes prolong the action potential of isolated cells, resulting in the QT prolongation syndrome. Acquired causes of the long QT syndrome include drugs, electrolyte disorders and clinical syndromes due to other factors, such as HIV infection. The diagnosis of the long QT syndrome is based on clinical characteristics, electrocardiographic findings and family history. Short-term treatment aims at the prevention and correction of ventricular arrhythmias. Long-term treatment aims at shortening of the QT interval and the prevention of malignant arrhythmias.
Authors and Affiliations
M. PSALLAS, A. KOKKINOS, N. TENTOLOURIS
Keywords
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