THE LONG-TERM OUTCOME OF CYCLOPHOSPHAMIDE ORAL VERSUS INTRAVENOUS IN CHINESES CHILDREN WITH STEROID DEPENDENT NEPHROTIC SYNDROME
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 2
Abstract
Objectives: To investigate the effects of oral or intravenous cyclophosphamide with steroid dependent nephrotic syndrome(SDNS) children. Method: Sixty-nine SDNS children(39 girls and 30 boys) aged 1 to 14 years were treated with prednison and oral cyclophosphamide(OCP)(35cases) or with prednison and intravenous cyclophosphamide(IVCP) (34 cases). Essential investigations were done including blood count, renal function test, electrolytes, liver function test and Creatine-kinase isoenzyme(CK-Mb), Purified Protein Derivative(PPD), X-ray chest and urine analysis. Data were analyzed using appropriate SPSS 13.3 software for statistical test. Results: There were no statistically significant difference in children in two groups in age, sex, blood count, hemoglobin level, renal function, electrolytes, proteinuria, serum protein, albumin, cholesterol. Duration of remission were same in patients treated with IVCP and OCP. Side effects in patients treated with OCP were more than that in IVCP. Conclusion: The effects are similar in two groups, but side effects of OCP group are more than that in IVCP group. IVCP is a useful method for the SDNS children.
Authors and Affiliations
Hongzhu Lu
Keywords
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