The main optical characteristics of UV-spectra of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thiones derivatives

Journal Title: Фармацевтичний журнал - Year 2015, Vol 5, Issue 5

Abstract

The development of pharmaceutical chemistry confronts molecular spectroscopy the problem of calculating the electronic states, assumptions and explanations of the various properties of complex organic compounds. In recent years, following the basic optical characteristics of the electronic absorption spectra: the wave number of maximum absorption – νmax (in cm-1), the half-width of the absorption bands of – ∆ν1/2 (cm-1), the integral intensity of the absorption band (in l/mol·cm2), the oscillator strength of the electronic transition – f, the matrix element of the transition of electrons – Mik. began widely used. These constants allow you to determine the chromophores in the investigated substances, to establish the probability and the resolution of the electrons’ transition. Our goal was the calculation and study of the basic optical characteristics of the electronic absorption spectra of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thione, namely 5-(adamantane-1-yl)-4-methyl-1,2,4-triazole-3-thione and 5-(adamantane-1-yl)-4-phenyl-1,2,4-triazole-3-thione derivatives. When deciding about the purity of the compounds we used melting point, thin layer chromatography and the results of elemental analysis. UV spectra of the investigated compounds was measured with a spectrophotometer Specord 200-222U214 (Germany). Elemental analyzer GmbH (Germany) was used for carrying out the elemental analysis. It is determined that the values of the half-width Δν½ and integrated intensity of the absorption bands (A), the oscillator strength (f) and matrix element of the transition (Mik) can be used as an important constants of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thione derivatives for their identification and establishing a deep connection between spectra and structure of the molecule. For the studied compounds is the most characteristic absorption band in the medium wave spectrum with high values of A and f, which indicate about the permitted and probable transitions of electrons which give rise to the observed maxima. Based on the study of the basic optical characteristics of the electronic absorption spectra of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thione derivatives is found that chromatofor in the studied molecules is the structure of 1,2,4-triazole and substituents (adamantane, methyl and phenyl radicals). A distinctive feature, namely 5-(adamantane-1-yl)-4-phenyl-1,2,4-triazole-3-thione 5-(adamantane-1-yl)-4-methyl-1,2,4-triazole-3-tion are the values A, f, Mik, which can be used to identify the investigated compounds.

Authors and Affiliations

V. M. Odyntsova

Keywords

Related Articles

Organization of medical care for children in Ukraine (review of literature)

The realization of high quality medical measures for protecting children’s health remains an important issue at the stage of reforming the domestic medicine. The aim of this work was to study and analyze the system of me...

Investigation by development of technology of tincture for therapy of cardiovascular disease

Development of new original multicomponent herbal medicinal products for prevention and treatment of cardiovascular disease and atherosclerosis, with the use of medicinal plants growing on the territory of Ukraine, are o...

Problems of scientific substantiation of extemporaneous formulations technologies and ways of its solution. P a r t І. Retrospective view on the unification aspects of extemporaneous formulations

Extemporaneous formulations largely depend on practical experience and require constant analysis, the results of which should be reported to all the medical and pharmaceutical workers. The aim of the work is a retrospec...

Recent issues of medical and pharmaceutikal products supply to provide first aid for anti-terroristic operation (ATO) soldiers

Timely and high-quality health care in many cases is helping to save the life of the victim, the recovery of its combat capability and efficiency. In this, nurses plays an important immediate role as well as the entire s...

Expert evaluation of prescription drugs at the regional pharmaceutical market and its direction improvements

Low efficiency of state regulation of medicines in Ukraine led to the disruption of prescription drugs, which led to negative effects on the system of the pharmaceutical provision of the population: the improper prescrib...

Download PDF file
  • EP ID EP586603
  • DOI -
  • Views 62
  • Downloads 0

How To Cite

V. M. Odyntsova (2015). The main optical characteristics of UV-spectra of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thiones derivatives. Фармацевтичний журнал, 5(5), 57-62. https://europub.co.uk/articles/-A-586603