The mechanism of autophagy inducing drug resistance of hepatocellular carcinoma
Journal Title: Journal of Clinical Hepatology - Year 2024, Vol 40, Issue 11
Abstract
Treatment resistance of hepatocellular carcinoma （HCC） is an important factor restricting its treatment outcome. Autophagy is a process involving multiple steps and targets and is closely associated with the proliferation and apoptosis of tumor cells. At the same time， there is significant crosstalk between autophagy and tumor treatment resistance. Therefore， autophagy may be one of the key factors hindering tumor cell death after medical intervention. Transforming growth factor-β （TGF-β）， epithelial-mesenchymal transition （EMT）， and long non-coding RNA （lncRNA） are important factors leading to drug resistance of HCC. This article discusses the possible mechanism of TGF-β， EMT， and lncRNA mediating complex molecular networks and inducing drug resistance of HCC， in order to provide new ideas for improving the sensitivity of HCC treatment.
Authors and Affiliations
Runbing ZHANG, Tingting SHI, Yang WU, Jiucong ZHANG, Xiaofeng ZHENG
Keywords
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- EP ID EP753490
- DOI 10.12449/JCH241128
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