The mechanism of Xuefu Zhuyu decoction in treating erectile dysfunction based on Arrowsmith tool
Journal Title: TMR Integrative Medicine - Year 2021, Vol 5, Issue 13
Abstract
Arrowsmith, a literature retrieval tool, was used to explore the theoretical pharmacological mechanism of action of Xuefu Zhuyu decoction and its single herb against erectile dysfunction. Cytoscape 3.6.1 software was used to analyze the correlation between the components of Xuefu Zhuyu decoction and the identified mechanism of action. Different herbs in Xuefu Zhuyu decoction may play a therapeutic role by regulating iNOS, COX-2, mTOR, Wnt, AMPK, Nrf2, TLR4, CYP2D6, BDNF, MAPK, Akt, STAT3, PI3K, ERK1, P38MAPK, JNK, VEGF, and other targets. The treatment of erectile dysfunction with Xuefu Zhuyu decoction embodied the multicomponent, multitarget, and multipathway. The Arrowsmith tool retrieval and analysis provided a scientific basis for further elucidation of the mechanism of Xuefu Zhuyu decoction against erectile dysfunction.
Authors and Affiliations
Hai-Yuan Dong, Chao-Gang Gan, Jing-Yu Guo, Tao Li, Yong-Heng Ao, Wen-Li Luo, Shi-Lin Ding
Keywords
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- EP ID EP697492
- DOI 10.12032/TMRIM202105013
- Views 66
- Downloads 0
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