THE MEDICAL MYCOLOGY AND THE LEGACY OF ANTONIO GONZALEZ OCHOA
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 6
Abstract
This work presents an approach of the scientific work of Dr. Antonio González-Ochoa, prominent Mexican mycologist and dermatologist. His research had a deep transcendence in the national and international medical mycology. Highlights the isolation and identification for the first time of Histoplasma capsulatum, Fonsecae pedrosoi var. cladosporioides and Actinomyces mexicanus, synonym of Actinomyces brasiliensis. The study of actinomycetes contributed to the reclassification of species and confirmation of the four current genera of medical importance: Actinomyces, Actinomadura, Streptomyces and Nocardia. His clinical classification of mycoses, extended to histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, candidosis and sporotrichosis, for a better understanding of these mycoses. In histoplasmosis and coccidioidomycosis, his contributions on the epidemiology and geographic distribution are classic, applying about 40, 000 and one million tests with histoplasmin and coccidioidin. In the dermatophytosis showed in the histopathology, that the lesions are of the allergic eczematous dermatitis type, produced by an allergen released by fungi. He was a pioneer in obtaining polysaccharide antigens in actinomycete mycetoma and sporotrichosis, along with metabolic antigens in histoplasmosis, coccidioidomycosis, aspergillosis, candidiasis and paracoccidioidomycosis, allowed to establish immunological tests, which facilitated the diagnosis and prognosis of these mycoses. The development of the first experimental model in animals on the reproduction of actinomycetic mycetoma and chromomycosis, was determinant for the investigations on pathogenicity and virulence of the Nocardia species, and continues to evaluate drugs in the treatment of these mycoses. In the most relevant mycoses for Mexico, histoplasmosis, coccidioidomycosis, cryptococcosis and dermatophytosis, we have updated the epidemiological panorama with the recent investigations developed in recognition of his work as a researcher and his contributions to medicine.
Authors and Affiliations
Dr. José D. Méndez
Keywords
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