The Metabolic Syndrome in Adolescents Age 11-18 Years with Familial History of Early Onset Type 2 Diabetes (T2DM)

Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 18, Issue 7

Abstract

Background: Some studies have noted an association between family history of diabetes and the Metabolic Syndrome (MS) in childhood. Aim: To determine the prevalence rate of the metabolic syndrome in adolescents with familial history of early onset (T2DM) and BMI < 95th percentile for age. Study Design: A cross-sectional analysis. Place and Duration of Study: Department of Basic Medical Sciences University of the West Indies, Jamaica, 2012. Methodology: Anthropometric and biochemical measurements were evaluated for 25 adolescents 11-18 years of BMI < 95th for age and family history of early onset T2DM. Thirty two (32) adolescents of similar age and BMI without familial history of diabetes served as controls. Measurements included: Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), fasting glucose, glycosylated hemoglobin (HbA1c), insulin, BMI, waist circumference and insulin resistance (HOMA-IR). The prevalence rate of MS was determined in the childhood/adolescence criteria as recommended by the National Cholesterol Education Program Adult Treatment Panel Third (NCEP-ATP III) modified standard. Results: Sixteen percent (16%), 16% and 20% of adolescents with familial history of early onset T2DM had glucose intolerance, dyslipidemia and abdominal obesity respectively. Twenty percent of these adolescents were insulin resistant and 8% were diagnosed with diabetes mellitus. Approximately 3.1%, 9.4% and 6.3% of adolescents without familial history of diabetes had dyslipidemia, abdominal obesity and insulin resistance respectively. No adolescent presented with hypertension. The prevalence rate of MS in adolescents with familial history of early onset T2DM and BMI < 95th percentile for age was 19.1%. MS was not present in adolescents without familial history of diabetes. Conclusion: Adolescents of BMI < 95th percentile and family history of early onset T2DM are more likely to develop MS than adolescents of similar BMI without family history of diabetes.

Authors and Affiliations

Rachael Irving .

Keywords

Related Articles

CYP17, CYP19, and NQO1 Genetic Polymorphisms and Breast Cancer Susceptibility in Young Women in Brazil

Aims: Breast cancer is the most common cancer in women worldwide, being exposure to estrogens the acknowledged main risk factor. CYP17, CYP19 and NQO1 are enzymes involved in the estrogen metabolism, so their polymorphis...

Craniofacial Reconstruction of the Skull in Anterior Plagiocephaly: A Case Report

Anterior plagiocephaly is the third most common form of non-syndromic craniosynostoses and results from the premature unilateral fusion of the coronary suture. The main features consist of forehead, supraorbital arch and...

Blood Parameters and Spleen Histology Following Chronic Consumption of Ethanolic Extract of Costus afer Stem and Juice on Albino Wistar Rats

Aim: Costus afer is a medicinal plant used as a therapy for diabetes and hypertension. This study investigated the effect of crude ethanolic extract of Costus afer (Monkey sugar cane) stem and its juice on the histology...

Screening for Glucokinase (GCK) Gene Mutation in Gestational Diabetes Women in Western Region of Saudi Arabia

Aim: The study involved screening of three exons of glucokinase gene (7, 8 and 9) to detect mutations at posi¬tions 682A>G, p.T228A, 895G>C, p.G299R and 1148C>A, p.S383X, respectively in Saudi pregnant women with or with...

Exploring Medicine Information Needs of Hypertensive Patients Using Short Message Service

Aims: To explore the pattern of unmet medicine information needs of hypertensive patients on long term therapy and their attitude to use of SMS (mobile phone short message service) for medicine information exchange with...

Download PDF file
  • EP ID EP341013
  • DOI 10.9734/BJMMR/2016/26276
  • Views 53
  • Downloads 0

How To Cite

Rachael Irving . (2016). The Metabolic Syndrome in Adolescents Age 11-18 Years with Familial History of Early Onset Type 2 Diabetes (T2DM). Journal of Advances in Medicine and Medical Research, 18(7), 1-8. https://europub.co.uk/articles/-A-341013