The Modulatory Activity of Justicia carnea in Plasmodium Infected Mice
Journal Title: Trends Journal of Sciences Research - Year 2018, Vol 3, Issue 4
Abstract
The study investigated the antiplasmodial potency of Justicia carnea in plasmodium infected mice. The aqueous leaf extract of Justicia carnea was subjected to phytochemical screening using GC-FID. The suppressive, prophylactic and curative activity of the studied plant was accessed after oral administration of standard drugs (5mgkg-1 choroquine and 4mgkg-1 artesunate) and 400-800mgkg-1 of the extract. The effect of the aqueous leaf extract of the studied plant was also explored in the activities of liver enzymes, oxidative stress markers and hematological indices of plasmodium infected mice using spectrophotomertic methods and a hematology auto analyzer (BC 5300 Mindray England) respectively. The aqueous leaf extract of Justicia carnea showed considerable dose dependent antiplasmodial activity in the suppressive, prophylactic and curative test conducted. The suppressive activity of (92%) of the aqueous leaf extract of the studied plant at 800mgkg-1 was comparable to the standard drugs used while the mean survival time of plasmodium infected mice at 800mgkg-1 was beyond the mean survival time of the infected untreated group. The aqueous leaf extract of the studied plant also exhibited significant improvements in the activities of liver enzymes, oxidative stress markers and some hematological parameters at 800mgkg-1 of the extract when compared with the infected and untreated group. The results of the study exhibited the antiplasmodial activity of the studied plant, nonetheless, the crude extracts of the studied plant can be further purified for synergistic use with other potent antimalarial drugs to combat and achieve total clearance of plasmodium resistant infections.
Authors and Affiliations
Alozie S. Chidi, Wegwu O. Mattew, Amadi A. Benjamin, Njoku C. Uche
Keywords
Related Articles
- EP ID EP438993
- DOI 10.31586/Biochemistry.0304.02
- Views 91
- Downloads 0
Orientation on Electron-Transfer Nature for Oxidation of Some Water-Soluble Carbohydrates: Kinetics and Mechanism of Hexacholroiridate (IV) Oxidation of Methyl Cellulose in Aqueous Perchlorate Solutions
The kinetics and mechanism of oxidation of methyl cellulose (MC) polysaccharide by hexacholroiridate (IV) in aqueous perchlorate solutions at a constant ionic strength of 0.1 mole dm-3 has been investigated, spectrophoto...
Acuros XB for Dose Calculations in External Beam Photon Radiotherapy-Mini Review
Dose calculations based on Monte Carlo (MC) often require sophisticated treatment planning stations with long processing time, and this could be issue for many cancer centers. Hence, most of the commercial treatment plan...
Red Cell Distribution Width and Neutrophil/lymphocyte Ratio in Bare Metal Coronary Artery Stent Restenosis
Background: Coronary stents are commonly used to treat obstructive coronary artery disease. It is currently difficult to reliably predict in-stent restenosis. The aim of this study was to examine the relationship between...
Spontaneous Migration of Central Venous Catheter to Anterior Mediastinum
Central venous devices are routinely used in delivering chemotherapy and total parenteral nutrition. Spontaneous migration of central venous catheters is a very rare complication, but the etiology of this problem is not...
Study on the Relationship between Yogurt Packages, Drinking Methods and Residues and the Countermeasures
The aim of the study was to evaluate the relationship between different yogurt packages, drinking methods, and residues and the countermeasures. We chose 7 of the most common yogurt packages in the Chinese market, calcul...