The molecular adsorbent recirculating system as a liver support system. Summary of Mexican experience
Journal Title: Annals of Hepatology - Year 2014, Vol 13, Issue 2
Abstract
Aim. The aim of this study was to assess the effects of the molecular absorbent recirculating system (MARS) on patients with acute liver failure (ALF) and liver failure with cirrhosis (AoCLF) as well as in cholestatic patients with intractable pruritus in a Mexican population. Material and methods. From August 2003 to December 2011, MARS was used in 38 patients with ALF, 15 patients with AoCLF, and 17 cholestatic patients with intractable pruritus. The patients were examined using a standard liver function test and for vital signs, presence of ascites and encephalopathy before and after each treatment. The therapeutic response, patient status, follow-up status, and need for liver transplantation were determined. Results. Seventy-nine MARS procedures were performed. MARS was used for ALF in 54.3% of patients, AoCLF in 24.2%, and cholestatic disease in 21.5%. There were significant improvements in serum bilirubin (p = 0.000), aspartate aminotransferase (p = 0.000), alanine aminotransferase (p = 0.030), gamma-glytamyl transpeptidase (p = 0.044), alkaline phosphatase (p = 0.006), and encephalopathy grade (p = 0.000). Thirty-eight ALF patients were listed for emergency liver transplantation and treated with MARS; 20 of these patients died on a waiting list, 18 survived. only four underwent liver transplantation and 14 (37%) recovered without transplantation after the MARS procedure. Conclusion. MARS is a safe and effective procedure, especially for ALF patients. Our results suggest that MARS therapy can contribute to native liver recovery in ALF patients.
Authors and Affiliations
Laura Cisneros-Garza, Ma. del Rosario Muñoz-Ramírez, Linda Muñoz-Espinoza, José Ruiz Velasco, Rosalba Moreno-Alcántar, Eduardo Marín-López, Nahum Méndez-Sánchez
Keywords
Related Articles
- EP ID EP78380
- DOI -
- Views 126
- Downloads 0
Effectiveness of add-on Pegylated interferon alfa-2a therapy in a Lamivudine-treated patient with chronic hepatitis B
Hepatitis B virus (HBV) surface antigen (HBsAg) to anti-HBsAg (anti-HBs) antibody seroconversion is the best, final objective for all available chronic hepatitis B (CHB) treatments. Unfortunately, this goal is rarely obt...
Use of proteomic analysis tools to identify HCV-proteins down-regulated by acetylsalicylic acid
Background and aim. Acetylsalicylic acid (ASA) has been shown to downregulate HCV expression; however, the involved mechanisms are unknown. We used proteomic analysis to compare protein expression profiles between human...
Mycobacterium avium complex in the liver
Alcohol effects on liver diseases: good or bad buddy?
Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant
Background and rationale. Acoustic radiation force impulse (ARFI) is a non-invasive tool used in the evaluation of liver fibrosisin HCV positive immune-competent patients. This study aimed to assess the accuracy of ARFI...