The Nucleus Accumbens Neurons Firing Pattern during the Extinction and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats: Electrophysiological Roles of Glutamate Receptors
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Background and Aim: The mesocorticolimbic dopaminergic system projecting from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) is necessary for the initiation of opioid compulsive usage and reward-associated behaviors. Activation of AMPA and NMDA glutamatergic receptors in the nucleus accumbens probably is a part of the mechanism of drug related reward. In this work, we investigated on the effects intracerebroventricular administration the AMPA (CNQX) and NMDA (AP5) antagonist on both extinction and reinstatement of morphine – induced conditioned place preference (CPP). All animals passed CPP procedure and afterwards, received intracerebroventricular administration of different doses of D-AP5 or CNQX during extinction period or reinstatement phase. In vivo single unit recording after the extinction period were performed in urethane anesthetized rats. After 20 min of baseline recording from accumbens neurons, the effective-dose or non-effective dose of morphine (1, 5mg/kg; s.c.) were performed and the spontaneous firing rate were continued to be recorded for 40 min. Our results showed that morphine decrease firing rate NAc neurons ICV microinjection D-AP5 or CNQX significantly increased baseline firing of the nucleus accumbens neurons. These findings suggested that glutamate receptors involve in extinction and reinstatement of morphine-CPP, and antagonism of these receptors may be useful for faster extinction of drug-induced reward and attenuation of relapse.
Authors and Affiliations
Ali Siahposht-Khachaki, Abbas Haghparast, Sayed Ali Noorbakhsh
Keywords
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- EP ID EP677935
- DOI 10.29088/GCNR-2020.26
- Views 176
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