THE OLFACTORY SYSTEM REGULATES ACUTE MOUNTAIN SICKNESS
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2009, Vol 5, Issue 1
Abstract
OBJECTIVE: Hyperventilation is the first response to hypoxia in high altitude (HA). Our study on rats was designed to establish an integrated hypothesis to include hyperventilation, increased activity of hypothalamic- pituitaryadrenocortical axis (HPA) in response to initial exposure to hypoxia and failure of adaptation to stress in olfactory bulbectomised rats. METHODS: Albino rats whose olfactory lobes were removed were subjected to hypoxia and hypothermic conditions. Blood and urine samples were collected at various stages to measure biochemical parameters. Rats whose olfactory systems were intact were used as controls. RESULTS: The results suggested that the olfactory system regulated pituitary function and that in rats whose olfactory lobes were removed failed to adapt to the stress created by hypoxia and hypothermia. CONCLUSIONS: Acute Mountain Sickness (AMS) is a type of stress. Normal rats when subjected to stress such as AMS are able to adapt. This adaptation is lost when the olfactory bulbs are removed. It is postulated that serotonin receptors in the hypothalamus, through the splanchnic pathway regulate stress. This mechanism is independent of ACTH – Cortisol feed back system. Perhaps irregular and rapid respiratory rhythm simulates physiological Olfactory Bulbectomy during rapid climbing and AMS manifests as a failure of stress adaptation.
Authors and Affiliations
Savitha Nagabhushan, Thuppil Venkatesh, Vidyasagar Casikar
Keywords
Related Articles
- EP ID EP113133
- DOI -
- Views 106
- Downloads 0
ВЛИЯНИЕ МОНОЙОДАЦЕТАТА НА ТЕРМОТОЛЕРАНТНОСТЬ Clavibacter michiganensis ssp. sepedonicus И ДРОЖЖЕЙ SacCharomyces cerevisiae
В ходе поиска асептических агентов изучали комбинированное действие теплового шока (45ºС) и монойодацетата (МИА) на выживаемость Clavibacter michiganensis ssp. sepedonicus (Cms) и дрожжей Sacharomyces cerevisiae. При оп...
EFFECT OF HEAT STRESS IN TROPICAL LIVESTOCK AND DIFFERENT STRATEGIES FOR ITS AMELIORATION
Stress is a broad term, generally used in negative connotation and is described as the cumulative detrimental effect of a variety of factors on the health and performance of animals. Heat stress occurs in animals when th...
Change of fatty-acid composition in plants during adaptation to hypothermia
The study of inter-species variability of fatty acid composition in leaf tissues of three species of medicinal plants growing in Predbaikal’ye showed that this composition has a species-specific character. In the composi...
Изучение влияния разных концентраций кадмия на этиолированные проростки пшеницы (Triticum aestivum L.) и рапса (Brassica napus L.)
Изучено влияние высоких концентраций CdCl2 на этиолированные проростки пшеницы (Triticum aestivum L) и рапса (Brassica napus L). Установлено, что, если у рапса высокие концентрации кадмия сразу практически полностью инги...
The role of amino acids in improvement in salt tolerance of crop plants
The present work has been performed to study the growth and metabolic activities of maize and broad bean plants which are shown to have a degree of sensitivity to salinity and to determine the role of amino acids proline...