The Oral Mucosa: Subtypes of Epidermolysis Bullosa
Journal Title: Journal of Dental Health and Oral Research - Year 2020, Vol 1, Issue 1
Abstract
The oral cavity, which consists of the lips, vestibule, gums, hard and soft palates, tongue, tonsil, uvula and salivary glands, is covered by a superficial pluristratified epithelium. The oral mucosa includes masticatory, lining, or specialized layers. The basement membrane separates the epithelium from the mucosa. Subtypes of have been identified: Epidermolysis Bullosa Aquisita (EBA), Epidermolysis Bullosa Simplex (EBS), junctional, and dystrophic. Blisters are characterised in this genetic pathology as epidermolysis bullosa simplex (suprabasal), and Epidermolysis Bullosa Junctionalis (EBJ) (located in the different layers of the basement membrane). This form have distinct character by separation within epithelial keratinocytes, or between the epithelial cells and the basement membrane (Herlitz form, involving both the skin and the lamina propria, blistering occurring at sites of friction). Dystrophic Epidermolysis Bullosa (DEB) involves discontinuities in the underlying connective tissue. There is no efficient therapy for EB, resulting from genetic mutations. Treatment helps to control symptoms but not treat these disorders.
Authors and Affiliations
Michel Goldberg
Keywords
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- EP ID EP698991
- DOI http://dx.doi.org/10.46889/JDHOR.2020.1102
- Views 112
- Downloads 0
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