The particularities of management of patients with malignant tumors of adrenal medulla
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 8
Abstract
Pheochromoblastoma is a tumor developing from adrenal medulla and characterizing the severe course and high mortality level (15 %). Its severity is due to presence of not only malignancy but also catecholamine hyperproduction. The authors analysed the results of surgical treatment of 60 patients with pheochromoblastoma who were treated in surgical clinic in 1968–2017. The most effective method of treatment is surgery. The method of choice is a lumbotomic extraperitoneal access. The oncological radicality demands the complete tumor removal in a single capsule with the adrenal gland and revision of paranephric, paracaval and paraaortal tissues. Thirty eight (63.3 %) of 60 patients had 38 radical surgical procedures with following long-term remission. Three (5 %) patients had disease remission only after repeated surgery. Two patients live with the disease persistence, the drug management of which is easier than before surgery. Eight (13.3 %) patients had widespread metastatic process and they were referred for the symptomatic treatment. The recurrence after the primary surgery is a poor prognostic factor. The majority of patients (55.8 %) with the recurrence were incurable. In the rest of the cases, the operative treatment led to the long-term remission only in 71.9 % patients.
Authors and Affiliations
A. N. Kvachenyuk, D. A. Kvachenyuk
Keywords
Related Articles
- EP ID EP460093
- DOI 10.22141/2224-0721.14.8.2018.154856
- Views 74
- Downloads 0
Experience of Modern Premixed Insulin Use in Treatment of Diabetes Mellitus
No abstract
Mutual Influence of Thyroid and Carbohydrate Metabolism. Paradigms and Paradoxes
The article considers the influence of thyroid hormones on carbohydrate metabolism. The impact of thyroid hormones on carbohydrate metabolism depends on premorbid status, inherited predisposition to insulin resistance an...
Atypical Forms of Autoimmune Thyroid Disease Course as a Manifestation of Autoimmune Overlap Syndrome
Autoimmune thyroid disorders are relatively frequent pathology. The pathogenesis of all autoimmune diseases is based on disorders of the immune tolerance in genetically predisposed individuals, which lead to the developm...
Laboratory Diagnosis of Carbohydrate Metabolism Disorders. Diagnosis Algorithm in Hyperglycemic States
The article is devoted to the laboratory diagnosis of disorders of carbohydrate metabolism. Presents criteria for diagnosis of diabetes, an algorithm for oral glucose tolerance test, determine type of diabetes based on c...
Effect of metformin therapy on the levels of certain adipose tissue hormones and mediators of nonspecific generalized inflammation in patients with newly diagnosed type 2 diabetes
The aim of the study was to investigate the influence of the drug metformin on the levels of adipose tissue hormones and generalized nonspecific mediators of inflammation in type 2 diabetes. 38 patients with newly diagno...