The Pathophysiological Effects of Acrylamide in Albino Wister Rats
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 7
Abstract
Studies of the pathophysiological effects of suspected compounds are conducted in rodent species, especially rats and mice, to determine the potential toxic effects of a particular compound. In the assessment of acrylamide (ACR) which is available as a dietary compound in daily food stuffs, the potential toxicity was determined following the method described earlier. In this study, Albino Wister rats were used and were observed for clinical abnormalities, changes in food consumption, a n d s y m p t o m s o f toxicity over a period of two months following the oral administration of ACR. Among the parameters used to assess the effect of ACR were include ovarian histopathology, blood sugar, haemogram and lipid profile. The most notable clinical abnormalities observed in a few rats were a rough coat and decreased activity. None of the rats died or showedbehavioural change resulting from treatment with ACR. The concentration of serum biochemical parameters and haemogram showed significant differences between normal and treated rats. Histological examination of the ovaries of the treated rats showed great abnormalities as well. In fact, oral ACR doses are practically toxic with regard to rats after exposure for two months at a dose rate of 30 mg/kg, suggesting the compound is quite non-innocuous.
Authors and Affiliations
Shler Akram Faqe Mahmood| Department of Microbiology/Immunology, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaimani, Iraq, Kawa Amin| Department of Microbiology/Immunology, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Sulaimani, Iraq, Corresponding E- mail: kawa.amin@univsul.edu.iq, Heshu Sulaiman Rahman| Department of Medical Laboratory Sciences, College of Health Sciences, Komar University of Science and Technology, Sulaimani, Iraq, Department of Clinic and Internal Medicine, College of Veterinary Medicine, University of Sulaimani, Sulaimani, Iraq, Hemn Hassan Othman| Department of Anatomy and Histopathology, College of Veterinary Medicine, University of Sulaimani, Sulaimani, Iraq
Keywords
Related Articles
- EP ID EP11894
- DOI -
- Views 242
- Downloads 12
Care experiences and challenges of inpatients' companions in Iran's health care context: A qualitative study
Among the clients of nursing services, family members, as patient companions, serve as both caregiver and care receiver, such that specialized care is delivered by nurses and primary care is delegated to the patient com...
Comparing the complications of purse-string and simple ligation of appendix stump in appendectomy: A randomized clinical trial
Appendectomy is one of the most prevalent emergency surgeries in the world. In the present research, the consequences of closing off stump appendicitis via simple ligation versus purse-string were compared and contrast...
The Effects of Smoking on the Prostates of Rats which are Exposed to Cigarette Smoke
Background: Smoking is a hallmark preventable health issue worldwide. The role of smoking in the aetiology of prostate cancers remains a lack of consensus. Methods and material: 100 male albino Wistar rats were used. Th...
Intra-rater reliability of cervical sensory motor function and cervical reconstruction test in healthy subjects
Impairment of cervicocephalic and head joint position sense has an important role in the recurrent and chronic of cervicocephalic pain. The various tools are suggested for evaluating the cervicocephalic joint position s...
CONTRIBUTION OF FREQUENCY MODULATIONS TO THE PERCEPTION OF SPECTRALLY SHIFTED SPEECH IN QUIET AND NOISE
Cochlear implant is electronic device which is surgically implanted into the cochlea to provide the sense of hearing for hearing impaired individual who may not benefit from hearing aids. The current day’s cochlear i...