The Pathophysiology and Neurobehavioral Effects of Chlorfenapyr Insecticide in Lactating Female Sprague Dawley Rats and in HepG2 Cell Line
Journal Title: International Journal of Zoology and Animal Biology - Year 2020, Vol 3, Issue 5
Abstract
Chlorfenapyr (CFP) is good candidate insecticide for control of vectors blood borne diseases like malaria. As little information about CFP toxicity and possibility of its residue’s presence in food stuffs, milk and environment, we explore the postnatal toxic effects of CFP in female Sprague dawley rats and its pups. CFP was given orally at doses of 0,54 and 108 mg/kg to female albino rats immediately at first day after delivery till 21 days of lactation. All dams and its pups were weighted, euthanized and blood was separated for serum separation and tissues were preserved either at 4c as tissue homogenate for measurements of oxidant/antioxidants levels or in buffered formalin for histopathological examination. The highest dose of CFP induced hepatorenal toxicity in dams and its pups with evidence of increase liver enzymes and creatinine level when compared to control groups. Also, CFP displayed histopathological changes in liver, kidney, brain and spleen tissues of dams as well as rats’ pups after 21 days of treatment. The toxic effects resulted from secretion of CFP in milk and increased the free radicals’ production and oxidants like MDA in tissues of rats’ pups. Also, CFP had a cytotoxic effect on HepG2 cells indicated by induction of oxidative stress and lethality to cell line. Taken collectively, chlorfenapyr is a good candidate insecticide in vector control but had a cytotoxic effect in female albino rats, its pups, and in HepG2 cells.
Authors and Affiliations
Elalfy MM*, Abomosallam MS, Hamed MF, Elhadidy MG, Elazab ST and Mandour R
Keywords
Related Articles
- EP ID EP748200
- DOI 10.23880/izab-16000241
- Views 49
- Downloads 0
A Review on the Poisonous Spiders of Australia
A review of the poisonous spiders of Australia is made depending on the published and unpublished articles, books, and other information available on internet. Total 15 species of spiders have been identified as most da...
Bacterial Causes of Arthritis in Pigeons
Arthritis can be considered as a threat for production due to it causes losses. The condition is produced by multifactorial including include infection and mangemaetal factors. Bacterial infections including Salmonella...
Identification of Bacterial Species from Injured Cuticle of Mud Crab, Scylla serrata
Crustacean aquaculture production is one of the major economic activities worldwide with prime importance in the developing countries. Infectious diseases from viral, bacterial, and in some cases, fungal origin affectin...
Feeding Experiences of Paulownia Spp. Leaves: Potential Forage Source for Domestic Animals
Paulownia spp. is a very adaptable, fast growing and multi-purpose agroforestry tree. This species is a genus of Asian hardwood trees which have been cultivated there for the past 3000 years. They are native to much of...
Coupling Biorational Tactics with Radio-Genetic F1 Sterility Technique for an Effective Integrated Pest Management against Lepidopteran Insects
Insect pests belonging to Lepidopteran order species are amongst the most damaging pests of food and fiber crops globally. Lepidopteran pests are often managed imprudently by spraying crops with large amounts of broad-s...