The peculiarities of heart remodeling in patients after myocardial infarction with ST-segment elevation depending on the Lys198Asn polymorphism of endothelin 1 gene
Journal Title: Український терапевтичний журнал - Year 2018, Vol 0, Issue 3
Abstract
Objective — to investigate clinical and genetic aspects of associations of Lys198Asn endothelin 1 (EDN 1) gene polymorphism with the development of remodeling after myocardial infarction with ST-segment elevation (STEMI). Material and methods. The study involved 91 patients with STEMI, 70 (77 %) male and 21 (23 %) female, at average age (60.3 ± 9.4) years old after selective coronary angiography with infarct-related artery stenting. Polymerase chain reaction was used to determine allele polymorphism Lys198Asn of EDN 1 gene. The observation period duration was 6-month. Results and discussion. The association with the STEMI onset in male patients with Lys198Asn + Asn198Asn genotype of EDN 1 gene was in 3.19 times higher, then in female (c2 = 4.01, p = 0.043); at arterial hypertension presence — in 3.72 times (c2 = 4.31, p = 0.038), in tobacco smokers — in 2.06 (c2 = 4.66, p = 0.031), which was associated with more severe damages of the coronary arteries. In the acute STEMI period, the structural and functional data depending on polymorphous locus Lys198Asn of EDN 1 gene did not differ. After 6-month observations, in Asn-careers in comparison with Lys198sLys-careers, the increase in the left ventricular size and cavity volumes, and myocardial mass, as well as left atrium diameter. That is, there was a tendency to a progressive process of myocardial remodeling and the development of chronic heart failure. Conclusions. In patients after STEMI polymorphous Lys198Asn + Asn198Asn of EDN 1 gene in comparison with Lys198Lys genotype associated with the individual propensity to the formations of left ventricular dilatation and hence, the unfavorable (maladaptive) post infarctional remodeling.
Authors and Affiliations
O. V. Petyunina, M. P. Kopytsya, V. Yu. Galchinska, L. L. Pietienova
Keywords
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- EP ID EP457116
- DOI 10.30978/UTJ2018-3-4-40
- Views 112
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