The physiological role of nucleobindin-2/nesfatin-1 and their potential clinical significance
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2018, Vol 72, Issue
Abstract
Nucleobindin-2 is a multidomain protein. Nucleobindin-2 can be cleaved into three peptide products: nesfatin-1, nesfatin-2 and nesfatin-3. It has been also shown that both Nucleobindin-2 and nesfatin-1 exhibit anorexigenic effect in rodents. In this review, we focused on a systematic characteristic of Nucleobindin-2, its anorexigenic effect and discussed possible mechanisms of its action. The first one is associated with melanocortin system and is leptin independent. The second – involves neurons that produce orexigenic neuropeptide Y. This has allowed integrating key findings which have important implications for treatment of obesity. We also presented Nucleobindin-2/nesfatin-1 as proteins which might become potentially important for understanding and treatment of such diseases as epilepsy, acute appendicitis or cancer. It has been shown that the Nucleobindin-2 function in cancerogenesis may be dual. The high level of Nucleobindin-2 and nesfatin-1 expression was found in colony, breast and endometrium cancer cells. Additionally, Nucleobindin-2/nesfatin-1 induced the proliferation process of these cells. In the future, Nucleobindin-2/nesfatin-1 may be used as a potential biomarker in diagnosis. However, Nucleobindin-2/nesfatin-1 inhibited ovarian and adrenocortical cancer cells proliferation and stimulated its apoptosis. The action of both proteins involved variety of metabolic pathways. The knowledge about activity control of Nucleobindin- 2/nesfatin-1 may contribute to new breakthrough in medicine.<br/><br/>
Authors and Affiliations
Anna Skorupska, Andrzej Ożyhar, Dominika Bystranowska
Keywords
Related Articles
- EP ID EP423810
- DOI 10.5604/01.3001.0012.8132
- Views 136
- Downloads 0
Immunology of the eye
The eye is an organ of sight characterized by unusual immunological properties, resulting from its anatomical structure and physiology, as well as the presence of specific elements that, through the mechanisms of innate...
The CRISPR-Cas system – from bacterial immunity to genome engineering
Precise and efficient genome modifications present a great value in attempts to comprehend the roles of particular genes and other genetic elements in biological processes as well as in various pathologies. In recent yea...
Oxalobacter formigenes – charakterystyka i rola w rozwoju kamicy szczawianowo-wapniowej
Drobnoustroje są jednym z istotnych czynników mających znaczenie w powstawaniu kamicy moczowej. Podczas gdy bakterie ureolityczne i nanobakterie przyczyniają się do tworzenia kamieni to pałeczki Oxalobacter formigenes pe...
Ultrafiltration rate and diabetes as useful indicators of cardiovascular-related death in hemodialysis patients below 60 years of age
Background: The survival rate of elderly hemodialyzed (HD) patients is commonly thought to be poor. In a prospective, single center, non-interventional, observational study, the cause of all-cause and cardiovascular (CV)...
Synteza białek w bezjądrzastych płytkach krwi
Płytki krwi są najmniejszymi, pozbawionymi jądra komórkami krwi, które odgrywają główną rolę w utrzymaniu prawidłowej hemostazy. W organizmie człowieka każdego dnia wytworzonych zostaje około 1x1011 płytek krwi, które po...