The phytochemical components and acute toxicity of methanolic stem bark extract of Prunus africana
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 12
Abstract
currently there is a growing interest in use of medicinal plants. This has led to amplified need of scientific analysis of their safety and extractive phytochemical component, thus providing health care workers with adequate knowledge regarding the plants, and this in turn will assist patients make informed choice on their utilization. The bark extract of Prunus africana (P.africana) has been used traditionally for decades in the treatment of various conditions such as abdominal upset, decreased appetite, fever, malaria, prostate cancer, and benign prostatic hyperplasia. The stem bark of P.africana was evaluated for its phytochemical constituents and acute toxicity effect on fifteen female wistar rats. The bark extract was collected in Mukurweini in Nyeri County, Kenya. The bark extract of P.africana was soaked in methanol. The mixture was filtered and the organic solvent was evaporated to near dryness by vacuum evaporation using rotary evaporator. The bark extract was subjected to a phytochemical screening where extractive protocols were applied to detect majority of molecules present. The evaluation of acute toxicity of methanolic extract of the bark followed the modifiedLorke’s model. The phytochemical screening of the methanol bark extract revealed carbohydrates, flavonoids, tannins and saponins. The methanolic bark extract of P.africana at dose less than or equal to 5000 mg/kg body weight was found to be safe, therefore it isrelatively harmless based on Loomis and Hayes classification of acute toxicity.
Authors and Affiliations
Kanyoni J. Mwangi, Kweri J. Kariuki, Thuo Reuben, Kafaya G. Kibe
Keywords
Related Articles
- EP ID EP428656
- DOI -
- Views 77
- Downloads 0
Substance Abuse among Adolescents: 2. Prevalence and Patterns of Cigarette smoking among senior secondary school students in Abraka, Delta State, Nigeria
: Cigarette smoking is an important health hazard and a major preventable cause of morbidity and mortality. More young people are getting involved in tobacco use in Nigeria. This is of great concern. This study...
Duration-Dependant Effect of Exposure to Rubber Dust Particles on Lung Functional Status among Rubber Factory Workers
: Rubber dust particles affect the respiratory system by directly entering into the respiratory tract while breathing. We analysed the effect and the impact of duration of exposure to these dust particles on the...
Congenital Agenesis Of The Corpus Callosum With Intracerebral Lipoma And Frontal Encephalocele Presenting As A Case Of Unresolved Anterior Fontannel Swelling: A Case Report
Integration between the right and left cerebral hemispheres of the brain is important for proper function of the sensory, motor and higher cognitive activities. The corpus callosum which is the largest commissure in...
Serum Total Bilirubin levels in Diabetic Retinopathy - A case control study
ABTRACT: Introduction/ Back ground Diabetic retinopathy (DR), ending with loss of vision is one of the microvascular complications of Diabetes Mellitus (DM). Bilirubin, with potent antioxidant and anti-i...
Low beneficial effects of short term antidiabetic diet treatment in streptozotocin – induced diabetic rats
ABSTRACT: Oxidative stress is currently suggested to play a role in the pathogenesis of Diabetes mellitus. The role of dietary management in diabetes mellitus is to provide a proper balance of total nutrients...