The Phytochemical Properties and Antimicrobial Potentials of Aqueous and Methanolic seed Extract of Cola nitida(Vent.) and Cola acuminata (Beauvoir) grown in South West, Nigeria
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2016, Vol 2, Issue 12
Abstract
Abstract: The present study was undertaken to investigate the phytochemical constituents of two Nigerian grown kolanut and their antimicrobial properties. Extract of the seed of Cola nitida and Cola acuminata were used to determine the phytochemical constituent of aqueous and methanol nut extract and their solubility in the two solvents. Aqueous and methanol used reveals the solubility of these exrtacts in different solvent and the presence of secondary metabolites in the kola nut. Qualitative screening of the extracts of C. acuminata and C. nitidafor phytochemicalsrevealed the presence of alkaloid, saponins, tannins, flavonoids, glycoside, steroid, saponins glycoside, cardiac glycoside and the absence of anthraquinones in all the extracts.Quantitative analysis shows that the methanolic extracts C. acuminataand C. nitidahave the highest percentage of Saponins: (>10%) than the aqueous extract of the preparations. The disc method was used to determine the inhibitory effect of kolanut on the test microorganisms. Sensitivity patterns of zones of inhibition exhibited by the crude methanol and aqueous extract of Cola nitida and Cola acuminata shows that thenut possess relative degree of inhibitory effects against the test microorganisms: Staphylococcus aureus,Esherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and Lactobacillus respectively.. The zones of inhibition for K. pnemonia was the highest with 4mg/ml methanol extract of C. nitida and least for E.coli. As for C. acumunata,zones of inhibition for Lactobacillus was the highest with 4mg/ml methanol extract and least for P. aeruginosa. Highest zones of inhibition progressively increase from methanol to aqueous extract as their diameter of inhibition increases with increase in their concentration. The overall implication of the antimicrobial potentials of C.nitidaandC .acuminata in the development of drugs against infectious diseases and subsequent health improvement was highlighted. Keywords: Phytochemical properties, antimicrobial activity, Cola nitida, Cola acuminata, drug development
Authors and Affiliations
Efe M. Omwirhiren, Stephen A. James, Asefon O. Abass
Keywords
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