The Plasma Homocysteine Concentrations and Relationship with Insulin Resistance in Young Women with Polycystic Ovary Syndrome
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 2005, Vol 9, Issue 1
Abstract
Women with polycystic ovary syndrome (PCOS) have several cardiovascular disease risk factors including hyperinsulinemia. Hyperhomocysteinemia is a recognized risk factor for atherosclerosis and has recently to be correlated positively with the hyperinsulinemia. We examined the relationship between plasma homocysteine levels and insulin resistance in patients with PCOS. Forty women with PCOS and 35 healthy subjects were studied. Hormonal assays, lipid pofile, homocysteine and fasting insulin levels, insulin resistance indices like HOMA and QUICKI determinations and ultrasound evaluation were performed in all subjects. The mean fasting insulin levels were significantly higher in women with PCOS than control women ( 12.02 ± 7.6 vs 6.08 ± 2.09 μU/ml) where as no difference in fasting glucose concentrations was observed between groups. Insulin resistance indices (HOMA and QUICKI) were significantly different between PCOS and control group (p<0.001). We found significantly higher mean plasma homocysteine concentrations in patients with PCOS as compared with controls ( 11.5 ± 2.71 vs 9.4 ± 1.8 μmol/L, p=0.002). When patients were stratified by body mass index (BMI), the homocysteine concentration were significantly higher in both obese and normal-weight women with PCOS than control women (11.65 ± 2.3, 11.15 ± 1.9, 9.4 ± 1.8 μmol/L, respectively). Fasting insulin concentrations and and insulin resistance indices were significantly different in obese PCOS patients as opposed to normal-weight women with PCOS although both obese and normal-weight PCOS patients were more insulin resistant than normal healthy volunteers. As a result, insulin resistance in women with PCOS is associated with elevated plasma homocysteine, regardless of body weight and together with other risk factors like dyslipidemia or hyperinsulinemia, elevated homocysteine levels may contribute to the risk of cardiovascular disease in women with PCOS.
Authors and Affiliations
Berrin Çetinarslan, Zeynep Cantürk, Erdem Türemen
Keywords
Related Articles
- EP ID EP84400
- DOI -
- Views 98
- Downloads 0
Lithium lntoxication in Type 2 Diabetic Patient After Concurrent Use of Lisinopril and Lithium
Concurrent use of lithium with diuretics, ACE inhibitors and non-steroid antiinflammatory drugs may result in elevated serum lithium levels and lithium intoxication. We present here a case of lithium intoxication in a 75...
Evaluation of the Patients with Diabetic Foot Ulcerations
We recently reviewed diabetic patients with diabetic foot ulcers. Fifty-one patients (26 male, 25 female) with median age of 52 ( 8 years ) who were admitted to our department and hospitalized for diabetic foot ulceratio...
Investigating for Insulin Resistance and Type 2 Diabetes Mellitus in Obese Children
The incidence and prevalence of type 2 diabetes mellitus within the childhood period has increased in the worldwide, particularly among obese children. The aim of this study was to investigate impaired glucose tolerance...
Comparison of Papillary Thyroid Microcarcinoma and Carcinoma
Objective: The aim of this study is to evaluate some preoperative and postoperative clinical and histopathological characteristics of patients with papillary thyroid microcarcinoma (PTMC). We also compared these features...
Water and Salt Metabolism Disorders Following Transsphenoidal Pituitary Surgery
Transsphenoidal pituitary surgery is frequently complicated with mild to severe water and electrolyte disturbances in the postoperative period. These disorders are: transient diabetes insipidus, early or delayed hyponatr...