The Polymorphism of Regulatory Region of NOS3 Gene (rs2070744, Genotype CC) Protect Patients from Chronic Migraine
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 16, Issue 10
Abstract
Aims: There is evidence that endothelial nitric oxide synthase has a role in migraine pathophysiology. In our research, the role of SNP rs2070744 (c.-813C>T) in promoter region of NOS3 gene in the episodic and chronic forms of migraine is considered. Place and Duration of Study: University Headache Clinic between June 2012 and November 2014 and Department of Genetics, Faculty of Biology of Lomonosov Moscow State University between October 2013 and March 2016. Methodology: The study included 138 patients with migraine (44 with chronic and 96 with episodic migraine). The control group included 348 unexamined subjects. Genotypes were determined using real-time PCR with allelic discrimination test. Statistical processing was performed using Fisher test and Pearson's chi-squared test. Results: Our study evaluated the link of CC genotype of rs2070744 with migraine (Fisher’s p=0.026) and episodic migraine (Fisher’s p=0.022). Conclusion: Genotype CC of SNP rs2070744 in the regulatory region of NOS3 gene is more specific for episodic migraine and may prevents the chronification of migraine.
Authors and Affiliations
Eugene Klimov, Natalia Kondratieva, Kirill Skorobogatykh, Julia Azimova, Alexey Sergeev, Zarema Kokaeva, Elena Naumova, Andrey Rachin, Gyuzyal Tabeeva
Keywords
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- EP ID EP341156
- DOI 10.9734/BJMMR/2016/26738
- Views 53
- Downloads 0
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