THE POSSIBLE CARDIOPROTECTIVE EFFECTS OF DIFFERENT FRACTIONS OF ARTICHOKE EXTRACTS AGAINST 5-FU INDUCED CARDIOTOXICITY IN ALBINO RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: The present study aimed to evaluate the cardioprotective effects of ethyl acetate and methanolartichoke extracts(Cynara scolymus L.) against 5-Flurouracil (5-FU) induced cardiotoxicity in rats.Methods: Thirty-six albino rats were divided randomly and equallyin to six groups (each group with 6 rats): I, negative control, received (2 ml/kg/d)of dimethyl sulfoxide (DMSO) orally for 30 successive d; II, positive control, received (2 ml/kg/d) of (DMSO) orally for 30 successive d, and subsequently administered a single dose of 5-FU (150 mg/kg) by intraperitoneal injection on 27thd in assossiation with DSMO; III and V, received (200 mg/kg/d) of oral methanol and ethyl acetate artichoke extracts respectivelyfor 30 successive d; V and VI, received(200 mg/kg/d) of oral methanol and ethyl acetate artichoke extracts respectively for 30 successive d,with a subsequently received single dose of 5-FU (150 mg/kg) by intraperitoneal injection on 27th d of the experiment.Results: Prophylactic treatment of ethyl acetate and methanol artichoke extracts significantly attenuates the increased level of serum cardiac troponin T (CTn-T) and tumor necrosis factor-a(TNF-a)caused by 5-FU-induced cardiotoxicity in experimental albino rats while it increases the serum level of total antioxidant capacity (T-AOC).Conclusion: Results of the present study suggest that methanol and ethyl acetate artichoke extracts may be an effective modulator in mitigating 5-FU induced cardiotoxicity.Â
Authors and Affiliations
Safa Mustafa Najim, Intesar T. Numan, Maha N. Hamad
Keywords
Related Articles
- EP ID EP578249
- DOI -
- Views 68
- Downloads 0
AN EFFICIENT AND SIMPLE SYNTHESIS OF 2, 3-DIHYDRO-1, 3, 4-THIADIAZOLES, PYRAZOLES AND COUMARINS CONTAINING BENZOFURAN MOIETY USING BOTH CONVENTIONAL AND GRINDING METHODS
Objective: Green chemistry is the approach for synthesizing and using of chemicals that minimize risks to human and to the environments. The aim of this study describes the synthesis of some new thiadiazole, pyrazole and...
ESSENTIAL OILS AND METHYLGLYOXAL: A POSSIBLE ALTERNATIVE TREATMENT FOR ANTIBIOTIC RESISTANT BACTERIAL INFECTIONS
Objective: Essential oils are of significant interest in today’s world of healthcare because these compounds have a variety of medicinal properties. In this study, we evaluated the in vitro antibiotic role of essential...
BIOACTIVITY GUIDED FRACTIONATION AND ANTI-INFLAMMATORY ACTIVITY OF ACACIA NILOTICA PODS
Objective: The present study aims at screening the methanol extract and the tannin fraction of the pods of Acacia nilotica for anti-inflammatory activity. Methods: The methanol extract and its tannin fraction were evalua...
CHARACTERIZATION OF ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITIES OF INDIAN SALMON (ELEUTHERONEMA TETRADACTYLUM) PROTEIN HYDROLYSATES
Objective: The main aim of the present research was to evaluate the antioxidant and antiproliferative activity of Indian salmon (Eleutheronema tetradactylum) protein hydrolysates by pepsin and trypsin enzyme using In vit...
ANTIOXIDANT ACTIVITY OF FOURTEEN EULOPHIA SPECIES TRADITIONALLY KNOWN AS AMARKAND
Objective: Amarkand is a group of medicinal plants, of which tubers are regularly consumed by the tribal people in India as food and medicine. It has a strong background of regional ethnopharmacological and food uses. Th...