THE POSSIBLE PROPHYLACTIC EFFECT OF EGYPTIAN MORINGA OLEIFERA SEED OIL AS ANTI-ULCER ACTIVITY AND ANTI-INFLAMMATORY IN RATS.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 6
Abstract
Moringa oleifera Lam. is the multipurpose tree (therapeutic potential and nutritive value). In this work, authors focused on importance of Moringa oleifera seed oil (MSO) as antioxidant, anti-inflammatory and antiulcer. The search describes the lethal dose of 50 % (LD50), some Physico-chemical, antioxidant, antiulcer and anti-inflammatory of MSO. The results illustrated that the LD50 of MSO is more than 62.5 g/kg. MSO treated animals (250 and 500 mg/kg) a significantly decreased in the gastric juice, free acidity(FA) and total acidity (TA), also occurs improvement in pH of gastric juice(PH). There was a significant anti-ulcer activity, in ethanol-induced gastric ulcer of the MSO treated groups compared to ranitidine (R)( 197 mg/kg )as standard. Also, MSO (20 mg/kg, 72%) inhibited the carrageenan-induced inflammation in the hind paw of rats compared with ibuprofen (20 mg/kg, 33%) and mefenamic acid (100 mg/kg, 39%) as standard.
Authors and Affiliations
Sahar, B. A. | Biochemistry Department National Organization for Drug Control and Research (NODCAR), Giza 12553, Egypt, Rania, A. H. Abd El-Aal| Developmental Pharmacology Department, National Organization for Drug Control and Research (NODCAR), Giza 12553, Egypt
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