The potential effects of Caper (Capparis spinosa L.) in the treatment of diabetic neuropathy
Journal Title: Traditional Medicine Research - Year 2020, Vol 5, Issue 6
Abstract
Diabetic neuropathy (DN) is the most common form of neuropathy worldwide, with its prevalence rising alongside diabetes, and being characterized by sensory, motor or autonomic symptoms. DN is considered to be an incurable complication of diabetes, the management of which mainly consists of improving glycemic control, managing pain relief and ensuring continuous foot care. Although gabapentin, duloxetine and tricyclic antidepressants are commonly used to reduce patient symptoms, they do not affect the pathophysiology and progression of neuropathy. Furthermore, these drugs can have various side effects including insomnia, decreased appetite, arrhythmia, heart failure, and suicidal behavior. According to traditional Persian medicine, DN is recognized as a type of “Khadar” or “Esterkha” (a sensory or motor disorder, respectively) that occurs due to the accumulation of sugars in the peripheral nerves. Capparis spinosa L., commonly known as the caper plant, has been recommended in authentic sources of traditional Persian medicine to treat such disorders. In this study, we reviewed the pharmacological properties of C. spinosa using the Web of Science, PubMed, Scopus and Google Scholar databases, and found that Capparis spinosa L. could affect several pathways involved in DN pathogenesis, including aldose reductase activity, the secretion of inflammatory mediators (IL-17, TNF-α, IL-1β, IL-6), oxidative stress, hyperlipidemia, hyperglycemia and advanced glycation end product formation. Based on these findings, we hypothesize that Capparis spinosa L., may prevent the progression and reduce the symptoms of diabetic neuropathy, and so can be considered as a complementary treatment in this disorder. This hypothesis should be evaluated in well-designed in vitro and in vivo studies, and through clinical trials.
Authors and Affiliations
Hamid Reza Esmaeilpour,Reza Boostani,Ali Shoeibi,Mojtaba Mousavi Bazzaz,Roshanak salari,Mahdi Yousefi
Keywords
Related Articles
- EP ID EP690498
- DOI 10.12032/TMR20200223167
- Views 174
- Downloads 0
Tradition and Modern: Public Debate between Traditional Medicine Researcher and Philosopher
There have been disputes about traditional and modern medicine in the past hundreds of years continually since the recent western medicine was introduced into the eastern countries. The differences between the two system...
Two Empirical Formula for Hemostasis
Zhixue San Jin Yin Hua (Flos Lonicerae) 75g, Sheng Di (Radix Rehmanniae Recens) 75g,Bai Ji (Rhizoma Bletillae) 75g, Ma Bo (Lasiosphaera seu Calvatia) 75g, Er Cha (Catechu) 37g, Xue Jie (Sanguis Draconis)37g, Xue Yu Tan (...
Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis
Background: The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients. However, due to the uneven basic conditions and resea...
The marriage of Chinese Imperial Medicine and China Academy of Chinese Medical Sciences: privilege and benefits for the people
On September 27, 2019, the Palace Museum and China Academy of Chinese Medical Sciences held a signing ceremony of strategic cooperation at Jingsheng Zhai (The studio of esteemed excellence) in the garden of Jianfu Gong (...
Multidisciplinary integration to enhance the overall level of Chinese and Western medicine consensus efficacy
In recent years, Chinese and Western medicine clinical guidelines have attracted attention. But for the existing Chinese and Western medicine experts consensus or guidelines, Chinese medicine and Western medicine were sp...