The Potential of Ethanol Extract of The Yellow Root (Arcangelisia Flava L) As The Inhibitor of Enzyme Α-Glucosidase
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
The high prevalence of diabetes mellitus requires exploration on medicinal plants that can be used as an antidiabetic. Yellow root plant is one of the plants that are widely spread in Borneo which is used by people to treat diabetes. This study aims to determine the inhibition activity of the yellow root plant in inhibiting α-glucosidase enzyme that is believed to play an important role in the absorption of blood glucose. The results showed that the yellow root extracts containing bioactive compounds of flavonoids, alkaloids, very weakly inhibit the enzyme activity with the IC50 value is above 200 ppm. Allegedly the mechanism of yellow root stem as an antidiabetic not only by inhibiting the activity of the α-glucosidase enzyme, but also by stimulating the pancreatic β cells, thereby increasing insulin production or secretion
Authors and Affiliations
Raudhatul Fadhilah1 ,, Dedeh Kurniasih1
Keywords
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