THE POTENTIAL PROTECTIVE EFFECT OF ROASTED DATE PALM CAKE EXTRACTS (PHOENIX DACTYLIFERA L.) AGAINST NICKEL CHLORIDE-INDUCED INFERTILITY IN MALE MICE
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 11
Abstract
The powder date palm cake is sold in coffee and confectionary shops in the central region of the Kingdom of Saudi Arabia, where it is used as a hot drink in the form of decoction. It is alleged by users in the local community in Saudi Arabia to improve fertility. The date palm cake is the roasted grounded seeds of the date palm (Phoenix dactylifera L.). The objective of this study is to evaluate the potential protective effect of the date palm extracts against nickel chloride-induced infertility in male mice. The effects of nickel compounds on reproduction in rodent models are well documented. The method adopted is the injection of nickel chloride (10 mg/kg) intra-peritoneal to induce infertility in male mice. The chloroform and ethyl acetate extracts were used to assess their protective effects. Sperm abnormalities and testicular histopathology were evaluated. The results showed that the administration of chloroform extract enhanced the sperm count and reduced sperm abnormalities. Moreover, the abnormalities induced by nickel chloride were restored to a great extent compared to that of ethyl acetate extract. The chloroform extract also showed the highest total phenol and antioxidant activity, besides that it showed a reduction of empty spaces and decreased the germ epithelium distortion effects produced by the nickel chloride, however, the large dose of ethyl acetate induce mortality. This study partly aligned with the folk use of the date cake as a drink.
Authors and Affiliations
S. E. M. Eltom et al.
Keywords
Related Articles
- EP ID EP665539
- DOI 10.13040/IJPSR.0975-8232.10(11).4988-94
- Views 84
- Downloads 0
ASSESSMENT OF GREEN TEA EXTRACT ON TESTICULAR ACTIVITY IN STREPTOZOTOCIN-INDUCED DIABETIC SPRAGUE-DAWLEY RAT MODEL
Diabetes mellitus is a lasting metabolic disability regarding enhance etiology and permanent degenerating complications. Sexual abnormalities (Hypogonadism, infertility, etc.) are outfit a two of the discombobulate ingen...
SYNTHESIS OF NEFOPAM ANALOGUES AND CHARACTERISATION
Modified Benzoxazocine moiety of Nefopam with N-Protected-ethanolamine, fluorobenzene benzylbromide, 2,3-dimethyl-benzene, naphthalene, fluro-naphthalene. In these modification Friedel Craft alkylation plays vital role w...
GC- MS ANALYSIS AND IN-SILICO DOCKING ANALYSIS OF METHANOLIC EXTRACT OF FICUS RACEMOSA BARK
Indian medicinal plants are considered as a vast source of several pharmacologically active principles and compounds, which are commonly used in home remedies against multiple ailments. Plant secondary metabolites such a...
PROTECTIVE EFFECT OF PERILLYL ALCOHOL (POH) A MONOTERPENE: ON HIGH FAT DIET INDUCED HYPERLIPIDEMIA IN ALBINO WISTAR RATS A PRELIMINARY STUDY
To assess the effect of Perillyl alcohol (POH) on the lipid profile of high-fat-diet-induced hyperlipidemia in white male albino Wistar rats, the hyperlipidemia was induced by feeding cholesterol-rich high-fat diet for 4...
A COMPREHENSIVE REVIEW OF ALBIZIA PROCERA (ROXB.) BENTH.-AN UPDATE
Albizia procera is a genus of albizia, the member of legume family (fabaceae) and subfamily Mimosoideae. Albizia procera is tree with open canopy, occurs naturally in a wide distribution from India and Myanmar through So...