The Potential Role of Store-Operated Calcium Entry (SOCE) Pathways in the Pathophysiology of Epilepsy and Migraine-Like Headaches in Patients with Neurocysticercosis
Journal Title: Journal of Neurology, Neurological Science and Disorders - Year 2017, Vol 3, Issue 1
Abstract
Cysticercosis is the most common helminthic disease of the nervous system in humans. The clinical presentation of neurocysticercosis (NCC) is nonspecific and can mimic a wide array of primary central nervous system (CNS) disorders, making its diagnosis a challenge especially in endemic areas. The pathophysiology of episodic CNS manifestations of NCC is not well understood. We support the hypothesis that mechanisms used by cysticerci to escape the host’s immune system interfere with store-operated calcium entry (SOCE) pathways. This interference may modify brain excitability, leading to episodic manifestations like epilepsy and headaches.
Authors and Affiliations
Fogang Yannick Fogoum, Kamtchum-Tatuene Joseph, Kuate-Tegueu Callixte, Mbonda Paul Chimi, Ndiaye Moustapha, Gallo Diop Amadou
Keywords
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- EP ID EP560170
- DOI 10.17352/jnnsd.000011
- Views 41
- Downloads 0
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