THE PREGNANCY VARIABLE IN WOMEN WITH HETEROZYGOUS BETA THALASSAEMIA
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 4
Abstract
Objectives: This study was designed to determine the RBC indices and HbF and HbA2 levels of before and during pregnancy periods of heterozygous -thalassemia individual. Methods: The study was designed retrospectively among the 60 heterozygous individuals with heterozygous -thalassemia. In this study before and during pregnancy periods hematological outcomes of individual have been systematically documented. Results: The RBC indices were in non-pregnant group; Mean (min-max): RBC 4.98 mil/mm3 (3.81-5.80), Hb 11.76 g/dL (9-14.20), Hct 35.39% (30,20- 41) and HbF % 0.7, (0.3-1.4) and HbA2 % 4.28 (2.7- 4.7) pregnant group; RBC 3.93 mil/mm3 (2,34-5.23), Hb 10.31 g/dL (7,70-12.30), Hct 31.83 % (22,90- 37,60) and HbF % 2.37 (0.4-4.9), HbA2 % 4.87 (2.8-4.9) . The 30 heterozygous individuals with β-thalassemia of the non-pregnant group consisting of RBC, Hb and Hct levels were higher than the values in pregnant group. The difference between the two groups was statistically significant (P <0.05). The pregnancy related changes in HbF and HbA2 levels values have been observed in 30 pregnancies in 60 women with heterozygous β-thalassemia individual. Statistically significant increases in pregnancy period were observed. HbA2 level is elevated in pregnant women. Conclusion: According to the results obtained in this study; pregnancy is a preanalytical variable on individuals with heterozygous -thalassemia individual for RBC, Hb, Hct, HbF and HbA2 levels. For this reason; the decreasing values of RBC, Hb and Hct depends to pregnancy may cause to interpret of heterozygous individuals as homozygous.
Authors and Affiliations
Gülüzar Özbolat
Keywords
Related Articles
- EP ID EP637209
- DOI -
- Views 110
- Downloads 0
PROPHETIC MEDICINE IS THE SAFEST, CHEAPEST AND MOST EFFECTIVE ALTERNATIVE TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY FOR THE PREVENTION AND TREATMENT OF AIDS – A REVIEW
Prophetic medicine or Medicine of the Prophet (peace be upon him) comprises the divinely inspired words of therapy of Prophet Muhammad (peace be upon him). The Prophet (pbuh) made specific statements on 37 ailments and 6...
SOME HEAVY METAL ASSAY IN URINE OF BREAST CANCER AND BREAST CANCER FREE PATIENTS IN PORT HARCOURT, NIGERIA
Urine levels of Copper (Cu), Cadmium (Cd), Chromium (Cr), Lead (Pb), Nickel (Ni), and Zinc (Zn) were assayed in 150 patients using Atomic Absorption Spectroscopy (AAS). 100 of these test patients were pathologically and...
ROLES OF ANTHROPOMETRIC VARIATIONS AND SERUM HORMONAL (PROLACTIN AND ESTRADIOL) LEVELS ON THE INITIATION OF PRECOCIOUS PUBERTY
ABSTRACT Aims: The aim of the present study is to evaluate and compare prolactin and estradiol levels of selected male and female subjects within each sex group; as well as to determine subjects who may be potential cand...
EVALUATION OF FORENSIC CASES ADMITTED TO THE PEDIATRIC EMERGENCY SERVICE OF A HOSPITAL
Objective: In this study, it was aimed to investigate forensic cases admitted to the pediatric emergency department of a hospital. Material and Method: The present study was carried out at the Mersin Peripheral Obstetric...
RECONSTRUCTIVE - RESTORATIVE SURGERY FOR LOCALLY ADVANCED TUMORS OF THE OROPHARYNGEAL ZONE
Reconstructive surgeries for locally advanced malignant head and neck tumors are an integral part of rehabilitation activities and are aimed at improving cosmetic and functional results. Skin-muscular flaps on the leg wi...