THE PREGNANCY VARIABLE IN WOMEN WITH HETEROZYGOUS BETA THALASSAEMIA

Apply

THE PREGNANCY VARIABLE IN WOMEN WITH HETEROZYGOUS BETA THALASSAEMIA

Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 4

Abstract

Objectives: This study was designed to determine the RBC indices and HbF and HbA2 levels of before and during pregnancy periods of heterozygous -thalassemia individual. Methods: The study was designed retrospectively among the 60 heterozygous individuals with heterozygous -thalassemia. In this study before and during pregnancy periods hematological outcomes of individual have been systematically documented. Results: The RBC indices were in non-pregnant group; Mean (min-max): RBC 4.98 mil/mm3 (3.81-5.80), Hb 11.76 g/dL (9-14.20), Hct 35.39% (30,20- 41) and HbF % 0.7, (0.3-1.4) and HbA2 % 4.28 (2.7- 4.7) pregnant group; RBC 3.93 mil/mm3 (2,34-5.23), Hb 10.31 g/dL (7,70-12.30), Hct 31.83 % (22,90- 37,60) and HbF % 2.37 (0.4-4.9), HbA2 % 4.87 (2.8-4.9) . The 30 heterozygous individuals with β-thalassemia of the non-pregnant group consisting of RBC, Hb and Hct levels were higher than the values in pregnant group. The difference between the two groups was statistically significant (P <0.05). The pregnancy related changes in HbF and HbA2 levels values have been observed in 30 pregnancies in 60 women with heterozygous β-thalassemia individual. Statistically significant increases in pregnancy period were observed. HbA2 level is elevated in pregnant women. Conclusion: According to the results obtained in this study; pregnancy is a preanalytical variable on individuals with heterozygous -thalassemia individual for RBC, Hb, Hct, HbF and HbA2 levels. For this reason; the decreasing values of RBC, Hb and Hct depends to pregnancy may cause to interpret of heterozygous individuals as homozygous.

Authors and Affiliations

Gülüzar Özbolat

Keywords

COMPARISON BETWEEN RUTIN AND KAEMPFEROL CONTAIN IN ROOT AND LEA OF GLYCYRRHIZA GLABRA. L IN IRAQ

Glycyrrhiza glabra (family leguminosae), commonly known as licorice, is an herbaceous perennial and has been used as a flavoring agent in foods and medicinal remedies for thousands of years. Licorice root has been widely...

ORAL Α- TOCOPHEROL SUPPLEMENTATION AMELIORATES THE SERUM MALONDIALDEHYDE, SOD, GPX, CAT, GSSH, BLOOD LIPIDS AND GLYCEMIC CONTROL IN TYPE 2 DIABETIC SUBJECTS

Background: Vitamin E (α- tocopherol) is a natural anti oxidant vitamin found in large quantities in blood and cell membrane. The α-tocopherol exerts anti oxidant and anti lipid peroxidant activity and influences the ins...

EP ID EP637209
DOI -
Views 119
Downloads 0