The preparation of quinoxaline and 2,3-dihydropyrazine derivatives using Selectfluor as an efficient and reusable catalyst
Journal Title: Iranian Chemical Communication - Year 2015, Vol 3, Issue 1
Abstract
Selectfluor [1-(chloro methyl) -4-flouro -1,4-di azonia bicyclo[2,2,2] octane bis (tetraflouro-borate)] catalyzed the preparation of quinoxaline and 2,3-dihydo pyrazine derivatives through one -pot condensation of 1,2-di amines with 1,2-di carbonyls in solvent and under solvent- free conditions. This catalyst is commercially available, inexpensive, reusable, stable to air and moisture, and relatively non-toxic. Furthermore, very short reaction times, high yields of products, mild reaction conditions, absence of solvent, and easy work-up are other considerable advantages of these procedures. Also, a resonable mechanism has been proposed for the current reaction. The chemical structure and purity of the products were characterized by 1H NMR and IR spectroscopy.
Authors and Affiliations
Seyyedeh Fatemeh Hojati, Zahra Nematdoust, Toktam Zeinali
Keywords
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