The prognostic utility of Prox-1 expression in molecular subtypes of breast carcinomas
Journal Title: Medicine in Evolution - Year 2017, Vol 0, Issue 3
Abstract
Background: The assessement of Prox-1 expression in molecular subtypes of breast cancer might bring new prognostic data for approaching this pathology. Patients and Methods: A retrospective study of 45 cases of ductal carcinomas diagnosed between 2009 and 2013, including 20 axillary lymph nodes metastasis, was performed. The primary tumors and their corresponding lymph nodes were assessed histologically and immunohistochemically, taking into account the tumoral grading,staging and patients' age. Results: Out of 45 cases, 34 were luminal A. For these cases, the Prox-1 expression in tumor cells has correlated with the peritumoral lymphovascular microdensity (p=0,06). Referring to the lymph nodes metastasis, we observed a decrease of the Prox-1 expression in the lymphatic vessels and tumor cells, comparing to the primary tumors. Conclusion: The Prox-1 plays a key role in the tumor’s lymphangiogenesis process, its expression being usable also as a prognostic marker in evaluating breast cancer.
Authors and Affiliations
Bujor I. S. , Cioca A. R. , Ceaușu R. A. , Veaceslav F.
Keywords
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