The Prognostic Value of Lymph Node Ratio in Patients with Node-Positive Colorectal Cancer
Journal Title: Türk Kolon ve Rektum Hastalıkları Dergisi - Year 2017, Vol 27, Issue 3
Abstract
Aim: Lymph node metastasis is one of the most important prognostic factors in colorectal cancer. We investigated the prognostic value of lymph node ratio (LNR); (the ratio of the number of metastatic lymph nodes to the number of removed lymph nodes) in node-positive colorectal cancer patients. Method: We assessed 321 node-positive colorectal cancer patients. To determine the LNR threshold value that will separate patients in two prognostic groups with significantly different cancer-specific survival (CSS) rates, survival analyses were conducted with LNR threshold values between 0.05 and 0.95, at increments of 0.05. Results: In the whole series, the most significant LNR threshold value separating patients in low-risk (213 patients) and high-risk (108 patients) groups in terms of CSS was 0.40 (p<0.001) and LNR grouping had independent prognostic significance in multivariate Cox analysis (p<0.001). CSS of patients with tumor-node-metastasis (TNM) N1 and N2 disease was significantly different (p<0.001) and TNM nodal classification had independent prognostic significance in Cox analysis (p<0.001). When LNR and TNM nodal groupings were included together in the Cox analysis, LNR grouping maintained its independent prognostic significance (p<0.001), while TNM nodal grouping lost its prognostic significance (p=0.095). Conclusion: LNR is a stronger prognostic parameter than TNM nodal grouping in separating node-positive colorectal cancer patients into prognostic groups.
Authors and Affiliations
Nüvit Duraker, Zeynep Civelek Çaynak, Semih Hot
Keywords
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- EP ID EP274071
- DOI 10.4274/tjcd.83435
- Views 86
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