The Prognostic Value of β-catenin Expression in Endometrial Cancer
Journal Title: International Journal of Innovative Research in Medical Science - Year 2017, Vol 2, Issue 11
Abstract
Objective: To investigate the prognostic value of β-catenin expression in endometrial cancer. Methods: Immunohistochemistry was used to evaluate samples from 27 early stage and 39 advanced stage endometrial cancers. Smears were examined for the expression of β-catenin protein in the cell membrane, cytoplasm, and nucleus. The staining patterns were then evaluated for their correlation with several prognostic factors, including 5-year survival. Results: Decreased cell membrane β-catenin expression was significantly associated with advanced stage (stage III–IV), high grade (grade 3), deep (>50%) myoinvasion, and positive lymph node status (P < 0.05). Negative membrane staining for β-catenin was associated with a lower 5-year survival rate, compared to that for positive staining (51.7% vs. 86.6%, respectively; P < 0.05). Conclusions: Loss of membrane β-catenin expression is a strong and independent predictor of unfavorable outcomes in patients with endometrial carcinoma.
Authors and Affiliations
Yong Il Ji
Keywords
Related Articles
- EP ID EP450710
- DOI -
- Views 97
- Downloads 0
Atrial Fibrillation on Severe Sepsis in Resuscitation - About a Case
Severe sepsis associated with atrial fibrillation is rare in our practice. It is often responsible for heavy mortality. The immunodepression field (HIV 1) is an often unknown factor of severity that complicates sepsis. W...
Evaluation of Serum Uric Acid Levels in Essential Hypertensive Patients
Elevated serum uric acid concentration has been reported to be associated with an increased risk of coronary heart disease and is commonly encountered with essential hypertension, including untreated hypertension and typ...
Critical Care Intern Nurses Stressors and Their Management Strategies
Nursing has been identified as a stressful occupation. The transition from a student to new graduate can be stressful and ''is a reality shock''. Novice nurses have specific stressors that might be different from other n...
VIA /VILI Guided Cervical Punch Biopsy for Detection of CIN and Early Invasive Cervical Cancer in Low Resource Setting
Aim of Study - Evaluation of VIA/VILI guided cervical biopsy for diagnosis of cervical pre invasive and early invasive lesions of cervix for resource poor settings. Introduction and background - India has one fifth of bu...
Prevention of Transmission of Zika Virus at Point of Entries - Experience from International Airport, Mumbai
Introduction: Zika virus is a mosquito borne flavivirus. It is transmitted by the bite of the Aedes Aegypti mosquito. In July 2015 Brazil reported an association between Zika virus infection and Gullain-Barre syndrome. I...