The Prognostic Value of β-catenin Expression in Endometrial Cancer
Journal Title: International Journal of Innovative Research in Medical Science - Year 2017, Vol 2, Issue 11
Abstract
Objective: To investigate the prognostic value of β-catenin expression in endometrial cancer. Methods: Immunohistochemistry was used to evaluate samples from 27 early stage and 39 advanced stage endometrial cancers. Smears were examined for the expression of β-catenin protein in the cell membrane, cytoplasm, and nucleus. The staining patterns were then evaluated for their correlation with several prognostic factors, including 5-year survival. Results: Decreased cell membrane β-catenin expression was significantly associated with advanced stage (stage III–IV), high grade (grade 3), deep (>50%) myoinvasion, and positive lymph node status (P < 0.05). Negative membrane staining for β-catenin was associated with a lower 5-year survival rate, compared to that for positive staining (51.7% vs. 86.6%, respectively; P < 0.05). Conclusions: Loss of membrane β-catenin expression is a strong and independent predictor of unfavorable outcomes in patients with endometrial carcinoma.
Authors and Affiliations
Yong Il Ji
Keywords
Related Articles
- EP ID EP450710
- DOI -
- Views 102
- Downloads 0
Analysis of Oxidative DNA Damage in HIV- Positive Pregnant Women
Objective: Oxidative stress is central to Human Immunodeficiency Virus (HIV) pathogenesis. Increased oxidative stress leads to increased oxidative DNA damage in HIV infected patients. The objective of this study was to a...
Recurrent Prolonged Epileptic Fugue State Misdiagnosed as Psychosis? Tale of a Middle-Aged Female Nigerian African
A fugue is a state of reversible amnesia for personal identity in which case an individual wanders away from home or place of work for periods of hours, days or even weeks. It could be psychogenic (dissociative) or organ...
Otorhinolaryngology, Head and Neck Surgery Services in Khartoum State in Sudan 2015
Background: In Khartoum state, formal health services are heavily centralized. This is reflected by a specialist services coverage that is double the national ratio in Sudan, as is the case for other health services and...
Tragal Cartilage Versus Polytetrafluoroethylene (TEFLON) Partial Ossicular Replacement Prosthesis (PORP): A Comparative Study of Outcomes of Ossiculoplasty
Reconstruction of the conductive mechanism of the middle ear is one of the most intriguing topics in middle ear surgery. An implant in middle ear should be safe, biocompatible, stable, easily insertable and capable of yi...
Genetic Disorders a Bird View
Impairment in an individual DNA leads to the occurrence of genetic disorders. There are different factors which leads to the alteration in gene, chromosome. The alteration addition or deletion of particular gene or segme...