The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies
Journal Title: Balkan Medical Journal - Year 2019, Vol 36, Issue 2
Abstract
The introduction and advances on next-generation sequencing have led to novel ways to integrate simultaneous assessment of multiple target genes in routine laboratory analysis. Assessment of myeloid neoplasms with targeted next-generation sequencing panels shows evidence to improve diagnosis, assist therapeutic decisions, provide better information about prognosis, and better detection of minimal residual disease. Herein, we provide information for application and utilization of next-generation sequencing studies with a focus on the most important mutations in acute myeloid leukemia, myelodysplastic syndrome, myeloproliferative neoplasms, and other myelodysplastic/myeloproliferative neoplasms in order to integrate them into the daily clinical practice.
Authors and Affiliations
Fulya Öz Puyan, Serhan Alkan
Keywords
Related Articles
- EP ID EP534019
- DOI 10.4274/balkanmedj.galenos.2018.2018.1195
- Views 57
- Downloads 0
In Memory of Dr. Ratip Kazancıgil
.
Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis
Background: Carotid artery stenosis is the atherosclerotic narrowing of the proximal internal carotid artery and one of the primary causes of stroke. Elevated expression of the pleiotropic proinflammatory cytokine interl...
Management of Forgotten Ureteral Stents: Relationship Between Indwelling Time and Required Treatment Approaches
Background: Double-J stents are widely used in urology practice, and removal of these stents can sometimes be forgotten. Aims: To investigate whether indwelling time of double-J stent can predict which treatment modality...
Patient Privacy in the Era of Big Data
Protecting patient privacy requires various technical tools. It involves regulations for sharing, de-identifying, securely storing, transmitting and handling protected health information (PHI). It involves privacy laws a...
O6-methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Rectal Adenocarcinoma After Chemoradiotherapy Treatment: Clinical Implications
Aims: To analyze the clinical relevance of O6-methylguanine-DNA methyltransferase in rectal adenocarcinoma treated with chemoradiotherapy followed by surgery. Methods: Tissue samples from 29 rectal adenocarcinoma patient...