The Protective Effect of Coriandium sativum Extract on Hepato-renal Toxicity Induced in Irradiated Rats
Journal Title: European Journal of Medicinal Plants - Year 2014, Vol 4, Issue 2
Abstract
Aim: The aim of this study was to examine the effect of ethanolic extract of coriander leaves as a potent in vivo antioxidant agent in an effort of finding possible sources of antioxidants for future use in food and pharmaceutical formulations. Study Design: Randomized controlled experiment. Place and Duration of Study: Experimental Animal Unit, Drug Radiation Research Department, National Center for Radiation Research and Technology, Cairo Egypt. Methodology: Antioxidant activity of ethanol extract of coriander leaves was estimated by oxidative stress induced by radiation exposure with the dose of 4 Gy, Silymarin was used as a reference antioxidant drug in female albino rat. Results: Results of experiment revealed that radiation exposure caused a significant increase in serum caspase3 (0.870± 0.086), alanine transaminase (ALT) activity (24.43± 5.02) as well as urea (42.53± 6.11) and creatinine (0.865± 0.064) levels with an increase in liver and kidney lipid peroxidation (MDA) (307.0± 29.22 & 285.5± 48.93) respectively, while decrease in serum albumin (3.003± 0.355), protein (8.66± 0.436) as well as glutathione (GSH) contents of liver and kidney tissues (63.24± 12.19 & 17.38± 1.414) were estimated respectively. In addition serum globuline level and albumin /globuline ratio showed no significant changes. On the other hand, the administration of coriander (600 mg/kg bw) and silymarin (70 mg/kg bw) pre-treatment effectively prevented these alterations and maintained the antioxidant status. Conclusion: Data from present results revealed that Coriandum Sativum act as an antioxidant agent due to its free radical scavenging and cytoprotective activity.
Authors and Affiliations
H. A. Fahmy, N. H. Shreif, O. A. Gharib
Keywords
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- EP ID EP350054
- DOI 10.9734/EJMP/2014/7238
- Views 91
- Downloads 0
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