The protective effect of Pentoxifylline on testopathy in male rats following Dimethyl Nitrosamine administration: An experimental study

Journal Title: International Journal of Reproductive BioMedicine - Year 2019, Vol 17, Issue 10

Abstract

Background: Nitrosamines as a carcinogenic agent has unfavorable effects on some of the male reproductive parameters. Pentoxifylline (PX) is a xanthine derivative used as a drug inhibiting the inflammatory factors, reducing blood viscosity, improving peripheral blood flow, and so on. Objective: The aim of the present study is to evaluate the effects of PX against Dimethyl nitrosamine (DMN)-inducing the damage to the reproductive parameter of male rats. Materials and Methods: In this experimental study, 48 male Wistar rats (8 wk, 220- 250 gr) were randomly assigned to eight groups (n = 6/each): normal control and DMN control groups (40 mg/kg); PX groups (25, 50, 100 mg/kg), and DMN + PX groups (25, 50, 100 mg/kg). Treatments were administered intraperitoneally and the gavage applied daily for 28 days. The sperm parameters, spermatogenesis index, total antioxidant capacity, testosterone level, and seminiferous tube diameter were assessed. Results: The values of all parameters reduced significantly in the DMN control group compared to the normal control group (p < 0.001). The PX and PX + DMN treatments at all entirely doses improved all parameters significantly compared to the DMN control group (p < 0.001). Conclusion: DMN caused detrimental effects on reproductive parameters. Also, no significant modifications were observed in PX treatments at all doses compared to the normal control group. PX compensated the toxic effect of DMN on reproductive parameters.

Authors and Affiliations

Mohammad Reza Arabestani, Azita Faramarzi, Shiva Roshankhah, Cyrus Jalili

Keywords

Related Articles

Prevalence of premenstrual syndrome in Iran: A systematic review and meta-analysis

Background: Premenstrual syndrome (PMS) is a common disorder characterized by physical, mental and behavioral changes in the luteal phase of the menstrual cycle in the reproductive age women. Objective: The present study...

Prevalence of group B streptococcus colonization in Iranian pregnant women: A systematic review and meta-analysis

Background: Group B Streptococcus (GBS) is an important pathogen in newborns and pregnant women. Objective: The present study was carried out to estimate the prevalence of GBS colonization in pregnant women in Iran. Mate...

Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCT

Background: Clomiphene citrate (CC) is the first line agent used for ovulation induction in patients with polycystic ovarian syndrome (PCOS). However, there is marked discrepancy between the ovulation and pregnancy rates...

Stereological study on the effect of vitamin C in preventing the adverse effects of bisphenol A on rat ovary

Background: Bisphenol A (BPA), an environmental pollutant, can generate free radicals which damages the reproductive system. Vitamin C is an antioxidant which may prevent the adverse effects of free radicals. Objective:...

Reconstruction of mammalian oocytes by germinal vesicle transfer: A systematic review

Nuclear transfer procedures have been recently applied for clinical and research targets as a novel assisted reproductive technique and were used for increasing the oocyte activity during its growth and maturation. In th...

Download PDF file
  • EP ID EP671768
  • DOI -
  • Views 118
  • Downloads 0

How To Cite

Mohammad Reza Arabestani, Azita Faramarzi, Shiva Roshankhah, Cyrus Jalili (2019). The protective effect of Pentoxifylline on testopathy in male rats following Dimethyl Nitrosamine administration: An experimental study. International Journal of Reproductive BioMedicine, 17(10), -. https://europub.co.uk/articles/-A-671768