The Protective Effects of Safranal against Diabetes Mellitus and Its Complications
Journal Title: Annual Research & Review in Biology - Year 2017, Vol 14, Issue 6
Abstract
The increasing incidence of diabetes mellitus in all over the world is considered as a serious threat for human health. Oxidative stress is responsible for occurrence of diabetes by generation of oxygen free-radical, glycosylation of non-enzymatic protein, auto-oxidation of glucose, impaired glutathione metabolism, alteration in antioxidant enzymes, and formation of lipid peroxides. Oxidative stress also causes systemic inflammation, endothelial dysfunction, impaired secretion of pancreatic β cells and impaired glucose utilization in peripheral tissues. Recently, antioxidants have been focused as a therapy for diabetes. The present study has been designed to gather experimental in vitro and in vivo investigations on the anti-diabetic effects of safranal; however, the application has not fully understood. This review indicated the anti-diabetic effects of safranal related to its antioxidant and anti-inflammatory activities.
Authors and Affiliations
Mohammad Samini, Fereshteh Bafandeh
Keywords
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- EP ID EP313499
- DOI 10.9734/ARRB/2017/35478
- Views 96
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