The Protective Role of Strong Antioxidant Astaxanthin onBurn Wound and Burn-Induced Early Acute Kidney Injury through Abilities to Relieve Oxidative Stress and Inhibit Apoptosis by Modulating Mitochondrial-Apoptotic Pathways
Journal Title: International Journal Of Medical Science And Clinical Research Studies - Year 2022, Vol 2, Issue 12
Abstract
Summary: Burns are skin damage caused by heat trauma or cold trauma (frost bite).Causesincludefire,hotwater,electricity,chemicals,radiation,andcold(frostbite).Thisdamagemayinvolvesubcutaneoustissue.Burninjuriesareassociatedwithhighincidenceandprevalence,highriskofmorbidityandmortality,resource-intensive,andcostly.Oneofthemostcommoncomplicationsinburnpatientsisacutekidneyinjury(AKI).ThemechanismofearlyAKIafterburninjuryismultifactorial,andpreviousstudieshavemainlyfocusedonoxidativestressinjury,tubularapoptosis,andsystemicorlocalinflammation.Previousresults(fromourgroupandothers)suggestedthatROS-inducedoxidativestressdamageandapoptosisplayanimportantroleinthedevelopmentofearlyAKIduetoburninjury,andthat24hafterburninjuryareusefulforobservingchangesinburninjury.Itshowsthatitprovidesanimportanttimeframe.Kidneyfunctionandlevelsofoxidativestressandapoptosis.Astaxanthin(ATX)isanaturallyoccurringcarotenoidthatisreadilyobtainedfrommarineorganismsandstrongerantioxidanteffectsthanothercarotenoids.Giventhecriticalroleofoxidativestressandsecondaryrenalinflammationinsevereburn-inducedearlyAKI,aprotectiveroleofATXthroughitsanti-inflammatoryeffectsandpotentialmechanismsofactioninearlypost-burnAKIisreasonable.
Authors and Affiliations
Andi Muh. Octavian Pratama, Anwar Lewa
Keywords
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- EP ID EP739708
- DOI 10.47191/ijmscrs/v2-i12-37
- Views 3
- Downloads 0
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