The Relationship Between 25 (OH) Vitamin D Level and the Severity of Disease and Sleep Quality in Restless Legs Syndrome
Journal Title: Turkish Journal of Neurology - Year 2019, Vol 25, Issue 2
Abstract
Objective: Restless legs syndrome (RLS) is a common chronic sensory-motor neurologic disease with serious disabling effects on affected individuals’ physical and emotional health and quality of life. The underlying pathophysiology of the disease is not clear but iron metabolism disorders and dopaminergic dysfunction along with a genetic predisposition are blamed, and recently vitamin D deficiency was considered to play an important role in RLS. In this study, we aimed to investigate the relationship of concentrations of a vitamin D metabolite, 25 (OH) vitamin D, with RLS severity and quality of sleep. Materials and Methods: We enrolled 152 patients aged between 18 and 75 years who were referred to our general neurology outpatient clinic in Istanbul Training and Research Hospital, and diagnosed with RLS according to the International Restless Legs Syndrome Study Group diagnostic criteria, between September 2016 and September 2018. The patients were classified as the vitamin D deficiency group (<20 ng/mL, group 1) and normal vitamin D group (>20 ng/mL, group 2). Both groups were evaluated for their RLS severity index and Pittsburgh Sleep Quality Index (PQI). Both groups are compared statistically. Results: Of the 152 patients, 89 patients had low vitamin D concentrations (<20 ng/mL) (group 1) and 63 had normal vitamin D concentrations (>20 ng/mL) (group 2). There was no significant difference in terms of age, sex, body mass index, and cigarette consumption (p>0.05). There were significant differences between the two groups in terms of upper extremity involvement, ferritin concentrations, PQI, and RLS severity scores (p<0.05). Conclusion: The present study demonstrated that patients who are vitamin D deficient might have more severe RLS symptoms and an impaired quality of sleep compared with other patients with RLS.
Authors and Affiliations
Arife Çimen Atalar
Keywords
Related Articles
- EP ID EP48812
- DOI 10.4274/tnd.galenos.2019.25478
- Views 359
- Downloads 0
Synkinetic Spread and Hyperexcitability: Orbicularis Oris Recovery in Post-facial Synkinesis
Objective: Synkinesis after peripheral facial palsy is seen during spontaneous movements or reflex activity. The aim of the study was to investigate the recovery of the blink reflex (BR) R2-locked response on orbicularis...
Quantitative and Qualitative Assessment of Verbal Fluency in Amnestic Mild Cognitive Impairment
Objective: The objective of this research was to compare the verbal fluency skills of patients diagnosed as having amnestic mild cognitive impairment (aMCI) with the participants without neurologic or psychiatric problem...
Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis
no summary
Orolingual Angioedema After Intravenous Tissue Plasminogen Activator in a Patient with Insular Cortex Ischemia: A Case Report
Intravenous tissue plasminogen activator (tPA) increases survival rates without sequelae in acute ischemic stroke. Complications and management of this treatment have become more important with the increasing use of tPA....
What is the Effect of Accompanying Ankylosing Spondylitis in Treatment of Multiple Sclerosis? Is there a Resistance
no summary